慢性髓性白血病中一种看似简单的变异型Ph易位的复杂性
Complexity of an apparently simple variant Ph translocation in chronic myeloid leukemia.
作者信息
Morris C M, Fitzgerald P H
出版信息
Leuk Res. 1987;11(2):163-9. doi: 10.1016/0145-2126(87)90022-1.
A patient with chronic myeloid leukemia (CML) presented with an apparently simple Ph translocation t(19;22)(q13;q11). In-situ hybridization revealed movement of the c-abl oncogene from a cytogenetically normal chromosome 9 to the Ph. Bcr-3' and c-sis probes hybridized to distal 1p and not to the 19q+ chromosome as expected from the cytogenetic findings. We concluded that this patient had a complex translocation involving four chromosomes: t(1;9;19;22)(p36;q34;q13;q11).
一名慢性髓性白血病（CML）患者出现了一个看似简单的费城染色体易位t(19;22)(q13;q11)。原位杂交显示c-abl癌基因从细胞遗传学正常的9号染色体转移到了费城染色体上。Bcr-3'和c-sis探针杂交到1p远端，而未如细胞遗传学结果所预期的那样杂交到19q+染色体上。我们得出结论，该患者存在涉及四条染色体的复杂易位：t(1;9;19;22)(p36;q34;q13;q11)。
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