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载抗真菌药物硫酸钙珠作为治疗耳念珠菌感染的一种潜在疗法。

Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris.

机构信息

Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgowgrid.8756.c, Glasgow, UK.

Forth Valley Royal Hospital, Larbert, UK.

出版信息

Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0171321. doi: 10.1128/AAC.01713-21. Epub 2021 Oct 25.

Abstract

Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in health care units, particularly to patients undergoing surgery. The purpose of this study was to investigate the efficacy of antifungal-loaded calcium sulfate (CS) beads in combatting C. auris infection. We demonstrate that the CS-packed beads have the potential to interfere with planktonic and sessile C. auris.

摘要

耳念珠菌在临床上对全球医院感染构成了重大威胁。由于该生物体易于在皮肤生态位定植,因此它很可能继续对医疗机构构成威胁,特别是对接受手术的患者。本研究旨在探讨载抗真菌药物硫酸钙(CS)珠剂在治疗耳念珠菌感染方面的疗效。我们证明 CS 填充珠剂具有干扰浮游和定殖耳念珠菌的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c8d/8765289/4804d83ae44f/aac.01713-21-f001.jpg

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