Bristol Dental School, University of Bristol, Bristol, UK.
Faculty of Dentistry, University of Hong Kong, Hong Kong SAR.
J Med Microbiol. 2022 Jun;71(6). doi: 10.1099/jmm.0.001548.
is a recently emerged multidrug-resistant fungal pathogen that causes life-threatening infections to the human population worldwide. Recent rampant outbreaks of in coronavirus disease 2019 (COVID-19) patients, together with outbreaks in over 45 countries, highlight its threat to patients and healthcare economies. Unlike other pathogenic species, is capable of surviving in abiotic surfaces of healthcare facilities for prolonged periods, leading to increased risk of transmission within nosocomial settings. is resistant to multiple classes of antifungal agents, forms dry biofilms and transmits independently to regional epicentres, making its eradication from nosocomial environment arduous. The lack of strategies for environmental decontamination of from nosocomial settings is evident from the generic guidance and recommendations provided by leading global healthcare bodies. Therefore, this minireview discusses the current guidelines for environmental decontamination of and compounds and strategies currently under investigation for potential future use. While established guidelines recommend the use of products mainly consisting of sodium hypochlorite and hydrogen peroxide, initial works have been reported on the promising anti- properties of various other compounds and some biocompatible alternatives. Further validation of these approaches, coupled up with environmentally friendly decontamination protocols, are warranted to achieve superior elimination of from healthcare settings.
是一种新近出现的、具有多重耐药性的真菌病原体，对全球人类人口造成危及生命的感染。在 2019 年冠状病毒病（COVID-19）患者中，近期出现了 的猖獗爆发，再加上 45 多个国家的爆发，突显了其对患者和医疗保健经济的威胁。与其他致病性 物种不同， 能够在医疗机构的非生物表面长时间存活，导致医院环境中传播的风险增加。 对多种类别的抗真菌药物具有耐药性，形成干燥的生物膜，并独立传播到区域中心，使其难以从医院环境中根除。从领先的全球医疗保健机构提供的通用指南和建议中可以明显看出，缺乏针对医院环境中 进行环境消毒的策略。因此，本综述讨论了目前用于医院环境中 消毒的指南和化合物，以及目前正在研究用于未来潜在用途的化合物和策略。虽然既定指南建议使用主要由次氯酸钠和过氧化氢组成的产品，但已报告了各种其他化合物和一些生物相容替代品的有希望的抗 特性的初步工作。需要进一步验证这些方法，并结合环保的消毒方案，以实现从医疗保健环境中更好地消除 。
