Yale School of Medicine, New Haven, CT, USA.
Yale School of Medicine, New Haven, CT, USA.
Am J Otolaryngol. 2022 Jan-Feb;43(1):103267. doi: 10.1016/j.amjoto.2021.103267. Epub 2021 Oct 19.
In otolaryngology, it is important to minimize the use of opioids for post-operative analgesia given the rise in opioid abuse and mortality due to overdose in the United States. We sought to quantitatively determine the efficacy of non-opiate analgesia in postoperative pain management after microdirect laryngoscopy (MDL).
This is a single institution prospective study monitoring post-operative pain using a visual analog scale (VAS, 1-10). Patients with a history of vocal fold lesions, paralysis, and stenosis who underwent MDL were surveyed for one month following their procedure (daily for the first week and weekly thereafter). Student's t-test was used to determine whether short (1 week) and long term (1 month) pain was controlled by over-the-counter (OTC) medications. We defined adequate pain control as an average daily VAS score below 4 for the first 4 days and below 1 in the following 3 weeks and hypothesized that patients would report adequate pain control without the use of opioids.
Post-operative pain after MDL was generally mild. The average daily VAS score was 2.16 (95% CI [0.0-5.2], P = 0.0014) in the first 4 days post-procedure and 0.28 (95% CI [0.0-1.3], P = 0.0007) in the 3 weeks post-procedure confirming our hypothesis. On average, patients used 3.14 (CI: [0.0-12.8]) pills of acetaminophen and 0.57 (CI: [0.0-4.7]) pills of an NSAID per day in the first week. Only three patients required opioid analgesia, all of whom used opioids in the first 48 h.
OTC analgesics provide sufficient pain control after microdirect laryngoscopy for most patients. Given the potential for substance abuse from opioid medications, this study demonstrates that adequate pain control requires, at most, 48 h of opioid medications. Further study is needed to determine factors that contribute to increased pain after laryngoscopy.
在美国,由于阿片类药物滥用和过量导致死亡率上升,耳鼻喉科医生在术后镇痛中尽量减少阿片类药物的使用。我们旨在定量确定非阿片类镇痛药在显微直接喉镜检查(MDL)后术后疼痛管理中的疗效。
这是一项单机构前瞻性研究,通过视觉模拟量表(VAS,1-10)监测术后疼痛。对接受 MDL 治疗的声带病变、麻痹和狭窄患者进行了为期一个月的调查(术后第一周每天一次,之后每周一次)。使用学生 t 检验来确定短期(1 周)和长期(1 个月)疼痛是否可以通过非处方(OTC)药物来控制。我们将充分的疼痛控制定义为前 4 天平均每天 VAS 评分低于 4,随后 3 周内低于 1,并假设患者无需使用阿片类药物即可报告充分的疼痛控制。
MDL 后的术后疼痛通常较轻。术后第 1 天的平均每日 VAS 评分为 2.16(95%CI [0.0-5.2],P=0.0014),术后第 3 周的平均每日 VAS 评分为 0.28(95%CI [0.0-1.3],P=0.0007),证实了我们的假设。平均而言,患者在第一周每天使用 3.14 片(CI:[0.0-12.8])对乙酰氨基酚和 0.57 片(CI:[0.0-4.7])非甾体抗炎药,仅 3 名患者需要阿片类药物镇痛,所有患者均在术后 48 小时内使用阿片类药物。
对于大多数患者来说,OTC 镇痛药可在 MDL 后提供足够的疼痛控制。鉴于阿片类药物可能存在药物滥用的风险,本研究表明,充分的疼痛控制最多需要 48 小时的阿片类药物。需要进一步研究以确定导致喉镜检查后疼痛增加的因素。