在巴黎第一波和第二波疫情期间，对医护人员进行全院范围的前瞻性筛查，未发现有 SARS-CoV-2 再感染病例。
No SARS-CoV-2 reinfection among staff health-care workers: Prospective hospital-wide screening during the first and second waves in Paris.
机构信息
Département d'Informatique Médicale, Biostatistiques et Santé Publique, hôpital européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, 75015, France; Faculté de Médecine, Université de Paris, Paris, 75005, France.
Laboratoire de Virologie, Service de Microbiologie, hôpital européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, 75015, France; Unité de Génomique Fonctionnelle des Tumeurs Solides, Centre de Recherche des Cordeliers, INSERM, Université Paris, Paris, 75005, France.
出版信息
J Clin Virol. 2021 Dec;145:104999. doi: 10.1016/j.jcv.2021.104999. Epub 2021 Oct 19.
OBJECTIVES
Risk of reinfection with SARS-CoV-2 among health-care workers (HCWs) is unknown. We assessed the incidence rate of SARS-CoV-2 reinfection in the real-life setting of a longitudinal observational cohort of HCWs from the Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, France, during the first and second waves of COVID-19 epidemic.
METHODS
From March to December 2020, HCWs were subjected to molecular and serology testing of SARS-CoV-2. Reinfection was defined as a positive test result during the first wave, either by serology or PCR, followed by a positive PCR during the second wave. Evolution of COVID-19 status of HWCs was assessed by a Sankey diagram.
RESULTS
A total of 7765 tests (4579 PCR and 3186 serology) were carried out and 4168 HCWs had at least one test result during the follow-up period with a positivity rate of 15.9%. No case of reinfection during the second wave could be observed among 102 positive HCWs of the first wave, nor among 175 HCWs found positive by PCR during the second wave who were negative during the first wave.
CONCLUSIONS
SARS-CoV-2 reinfection was not observed among HCWs, suggesting a protective immunity against reinfection that lasts at least 8 months post infection.
目的
医护人员（HCWs）再次感染 SARS-CoV-2 的风险尚不清楚。我们评估了法国巴黎公立医院集团欧洲乔治·蓬皮杜医院（Hôpital Européen Georges Pompidou）纵向观察队列中 HCWs 在 COVID-19 大流行的第一波和第二波期间的真实环境中 SARS-CoV-2 再感染的发生率。
方法
2020 年 3 月至 12 月，对 HCWs 进行 SARS-CoV-2 的分子和血清学检测。再感染的定义为第一波通过血清学或 PCR 检测呈阳性，随后在第二波期间 PCR 检测呈阳性。通过 Sankey 图评估 HCWs 的 COVID-19 状态的演变。
结果
共进行了 7765 次检测（4579 次 PCR 和 3186 次血清学），在随访期间，4168 名 HCWs 至少有一次检测结果，阳性率为 15.9%。在第一波中 102 名阳性 HCWs 中，以及在第二波中 PCR 检测呈阳性但在第一波中为阴性的 175 名 HCWs 中，均未观察到第二波中的再感染病例。
结论
在 HCWs 中未观察到 SARS-CoV-2 再感染，表明感染后至少 8 个月对再感染具有保护性免疫。
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