Department of Cardiology and Angiology, University of Tuebingen, Tuebingen, Germany.
DFG Heisenberg Group Thrombocardiology.
Hamostaseologie. 2021 Oct;41(5):356-364. doi: 10.1055/a-1554-6416. Epub 2021 Oct 25.
Cardiovascular manifestations are frequent in COVID-19 infection and are predictive of adverse outcomes. Elevated cardiac biomarkers are common findings in patients with cardiovascular comorbidities and severe COVID-19 infection. Troponin, inflammatory and thrombotic markers may also improve risk prediction in COVID-19. In our comprehensive review, we provide an overview of the incidence, potential mechanisms and outcome of acute cardiac injury in COVID-19. Thereby, we discuss coagulation abnormalities in sepsis and altered immune response as contributing factors favoring myocardial injury. We further highlight the role of endothelial damage in the pathophysiological concepts. Finally, observational studies addressing the incidence of myocardial infarction during COVID-19 pandemic are discussed.
心血管表现是 COVID-19 感染的常见表现，并可预测不良结局。心血管合并症和重症 COVID-19 感染患者常有心脏生物标志物升高。肌钙蛋白、炎症和血栓形成标志物也可改善 COVID-19 的风险预测。在我们的全面综述中，我们概述了 COVID-19 中急性心脏损伤的发生率、潜在机制和结局。因此，我们讨论了败血症中的凝血异常和改变的免疫反应作为有利于心肌损伤的因素。我们进一步强调了内皮损伤在病理生理概念中的作用。最后，讨论了在 COVID-19 大流行期间发生心肌梗死的观察性研究。
