Independent Researcher, Clarksburg, MD 20871, USA.
Viruses. 2021 Sep 24;13(10):1923. doi: 10.3390/v13101923.
SARS-CoV-2, the etiologic agent at the root of the ongoing COVID-19 pandemic, harbors a large RNA genome from which a tiered ensemble of subgenomic RNAs (sgRNAs) is generated. Comprehensive definition and investigation of these RNA products are important for understanding SARS-CoV-2 pathogenesis. This review summarizes the recent progress on SARS-CoV-2 sgRNA identification, characterization, and application as a viral replication marker. The significance of these findings and potential future research areas of interest are discussed.
引发当前 COVID-19 大流行的病原体是 SARS-CoV-2，它带有一个大型 RNA 基因组，从中产生了一系列亚基因组 RNA（sgRNA）。全面定义和研究这些 RNA 产物对于了解 SARS-CoV-2 的发病机制非常重要。本综述总结了 SARS-CoV-2 sgRNA 鉴定、表征和作为病毒复制标记的应用方面的最新进展。讨论了这些发现的意义和潜在的未来研究领域。
