Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, India.
Department of Cancer Biology, Central Drug Research Institute, Lucknow, India.
Cancer Biol Ther. 2021 Dec 2;22(10-12):493-512. doi: 10.1080/15384047.2021.1992233. Epub 2021 Oct 25.
Tumor metastasis is the leading cause of cancer mortality, often characterized by abnormal cell growth and invasion to distant organs. The cancer invasion due to epithelial to mesenchymal transition is affected by metabolic and oxygen availability in the tumor-associated micro-environment. A precise alteration in oxygen and metabolic signaling between healthy and metastatic cells is a substantial probe for understanding tumor progression and metastasis. Molecular heterogeneity in the tumor microenvironment help to sustain the metastatic cell growth during their survival shift from low to high metabolic-oxygen-rich sites and reinforces the metastatic events. This review highlighted the crucial role of oxygen and metabolites in metastatic progression and exemplified the role of metabolic rewiring and oxygen availability in cancer cell adaptation. Furthermore, we have also addressed potential applications of altered oxygen and metabolic networking with tumor type that could be a signature pattern to assess tumor growth and chemotherapeutics efficacy in managing cancer metastasis.
肿瘤转移是癌症死亡的主要原因，其特征通常为异常细胞生长和向远处器官的侵袭。由于上皮间质转化导致的癌症侵袭受到肿瘤相关微环境中代谢和氧气供应的影响。健康细胞和转移细胞之间氧气和代谢信号的精确改变是理解肿瘤进展和转移的重要探针。肿瘤微环境中的分子异质性有助于在转移细胞从低代谢-低氧到高代谢-高氧部位的生存转变过程中维持其生长，并加强转移事件。本综述强调了氧气和代谢物在转移进展中的关键作用，并举例说明了代谢重编程和氧气供应在癌细胞适应中的作用。此外，我们还探讨了改变的氧气和代谢网络与肿瘤类型的潜在应用，这可能成为评估肿瘤生长和化疗疗效以管理癌症转移的特征模式。
