Department of Vascular Surgery, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China.
Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China.
Eur J Vasc Endovasc Surg. 2021 Dec;62(6):969-980. doi: 10.1016/j.ejvs.2021.08.010. Epub 2021 Oct 22.
Previous studies on the relationship between positron emission tomography (PET) images and abdominal aortic aneurysm (AAA) progression have shown contradictory results, and the objective of this study was to systematically review the role of PET in predicting AAA prognosis.
PubMed, Embase, and Web of Science were searched for studies evaluating the correlation between PET imaging results and AAA growth, repair, or rupture.
Two authors independently performed the study search, data extraction, and quality assessment following a standard method.
Of the 11 studies included in this review, nine used F-fluorodeoxyglucose (F-FDG) PET and computed tomography (CT) imaging, whereas the remaining two used F-sodium fluoride (F-NaF) PET/CT and F-FDG PET/magnetic resonance imaging (MRI). Findings from the F-FDG PET/CT studies were contradictory. Six studies found no significant association or correlation, and two studies found a significant negative correlation between F-FDG uptake and AAA expansion. Additionally, one study found that the F-FDG uptake was statistically positively related to the expansion rate in a specific AAA subgroup whose AAAs expanded significantly. Two studies suggested that increased F-FDG uptake was significantly associated with AAA repair, while the other studies either found no association between F-FDG uptake and AAA rupture or repair or failed to report the occurrence of clinical events. One PET/CT study that used F-NaF as a tracer showed that an increased tracer uptake was significantly associated with AAA growth and clinical events. Finally, the F-FDG PET/MRI study indicated that F-FDG uptake was not significantly correlated with AAA expansion.
A definitive role for F-FDG PET imaging for AAA prognosis awaits further investigation, and new PET tracers such as F-NaF have the potential to be a promising method for predicting AAA clinical outcomes.
先前关于正电子发射断层扫描（PET）图像与腹主动脉瘤（AAA）进展之间关系的研究结果相互矛盾，本研究旨在系统地综述 PET 在预测 AAA 预后中的作用。
检索了 PubMed、Embase 和 Web of Science 以评估 PET 成像结果与 AAA 生长、修复或破裂之间相关性的研究。
两名作者按照标准方法独立进行研究检索、数据提取和质量评估。
在本综述纳入的 11 项研究中，有 9 项使用了 F-氟脱氧葡萄糖（F-FDG）PET 和计算机断层扫描（CT）成像，而其余两项则使用了 F-氟化钠（F-NaF）PET/CT 和 F-FDG PET/磁共振成像（MRI）。F-FDG PET/CT 研究的结果相互矛盾。有 6 项研究未发现显著相关性或关联性，而有 2 项研究发现 F-FDG 摄取与 AAA 扩张之间存在显著负相关。此外，有一项研究发现，在特定的 AAA 亚组中，当 AAA 显著扩张时，F-FDG 摄取与扩张率呈统计学上的正相关。两项研究表明，F-FDG 摄取增加与 AAA 修复显著相关，而其他研究则发现 F-FDG 摄取与 AAA 破裂或修复之间没有关联，或者未能报告临床事件的发生。一项使用 F-NaF 作为示踪剂的 PET/CT 研究表明，示踪剂摄取增加与 AAA 生长和临床事件显著相关。最后，F-FDG PET/MRI 研究表明 F-FDG 摄取与 AAA 扩张无显著相关性。
F-FDG PET 成像在 AAA 预后中的明确作用尚待进一步研究，而 F-NaF 等新型 PET 示踪剂有可能成为预测 AAA 临床结局的有前途的方法。
