Department of Radiology, Keio University School of Medicine, Tokyo, Japan (T.N., R.M., Y.I., K.T., M.J.).
Division of Cardiology, Weill Cornell Medicine, New York, NY (N.N.).
Arterioscler Thromb Vasc Biol. 2024 Sep;44(9):1975-1985. doi: 10.1161/ATVBAHA.124.321110. Epub 2024 Jul 25.
Abdominal aortic aneurysms expand over time and increase the risk of fatal ruptures. To predict expansion, the isolated assessment of F-fluorodeoxyglucose (FDG) and sodium fluoride (NaF) uptake or calcification volume in aneurysms has been investigated with variability in results. We systematically evaluated whether F-FDG and F-NaF uptake was predictive of abdominal aortic aneurysm expansion.
Seventy-four male Sprague-Dawley rat abdominal aortic aneurysm models were imaged using positron emission tomography-computed tomography with F-FDG and F-NaF at 1, 2, 4, 6, and 8 weeks after CaCl or saline stimulation. In the 1-week cohort (n=25), the correlation between F-FDG or F-NaF uptake and pathological markers was investigated. In the time course cohort (n=49), animals received either atorvastatin, losartan, aldactone, or risedronate to assess the effect of these drugs, and the relationship between aortic size and sequential F-FDG and F-NaF uptake or calcification volume was examined.
In the 1-week cohort, the maximum standard unit value of F-FDG and F-NaF uptake correlated with CD68- (r=0.82; =0.001) and von Kossa staining-positive areas (r=0.89; <0.001), respectively. In the time course cohort, F-FDG and F-NaF uptake changed in a time-dependent manner and drugs attenuated this uptake. Specifically, F-FDG showed high uptake at weeks 1 and 2, whereas a high F-NaF uptake was noted throughout the study period. Atorvastatin and risedronate showed a decreased and increased aortic size, respectively. The final aortic area correlated well with F-FDG and F-NaF uptake and calcification volume, especially at 1 and 2 weeks (F-NaF [1 week]: r=0.61, F-FDG [2 weeks]: r=0.51, calcification volume [1 week]: r=0.59; <0.001). Multiple linear regression analysis showed that the combination of these factors predicted the final aortic size, with F-NaF uptake at 1 week being the strongest predictor.
The uptake of F-NaF and F-FDG and the calcification volume at appropriate times correlated with the development of abdominal aortic aneurysms, with F-NaF uptake being the strongest predictor.
腹主动脉瘤会随时间而扩张，并增加致命破裂的风险。为了预测扩张，已经研究了孤立评估 F-氟脱氧葡萄糖（FDG）和氟酸钠（NaF）摄取或动脉瘤中的钙化体积，但结果存在差异。我们系统地评估了 F-FDG 和 F-NaF 摄取是否可预测腹主动脉瘤的扩张。
74 只雄性 Sprague-Dawley 大鼠腹主动脉瘤模型在氯化钙或生理盐水刺激后 1、2、4、6 和 8 周时使用正电子发射断层扫描-计算机断层扫描进行 F-FDG 和 F-NaF 成像。在 1 周队列（n=25）中，研究了 F-FDG 或 F-NaF 摄取与病理标志物之间的相关性。在时间过程队列（n=49）中，动物接受阿托伐他汀、氯沙坦、螺内酯或利塞膦酸钠治疗，以评估这些药物的效果，并检查主动脉大小与连续 F-FDG 和 F-NaF 摄取或钙化体积之间的关系。
在 1 周队列中，F-FDG 和 F-NaF 摄取的最大标准单位值与 CD68-（r=0.82；=0.001）和 von Kossa 染色阳性区域（r=0.89；<0.001）分别相关。在时间过程队列中，F-FDG 和 F-NaF 摄取呈时间依赖性变化，而药物则减弱了这种摄取。具体来说，F-FDG 在第 1 周和第 2 周摄取量较高，而 F-NaF 摄取量在整个研究期间均较高。阿托伐他汀和利塞膦酸钠显示主动脉大小减小和增大，分别。最终的主动脉面积与 F-FDG 和 F-NaF 摄取以及钙化体积密切相关，尤其是在第 1 周和第 2 周（F-NaF [1 周]：r=0.61，F-FDG [2 周]：r=0.51，钙化体积 [1 周]：r=0.59；<0.001）。多元线性回归分析显示，这些因素的组合可预测最终的主动脉大小，其中第 1 周的 F-NaF 摄取是最强的预测因子。
F-NaF 和 F-FDG 的摄取以及在适当时间的钙化体积与腹主动脉瘤的发展相关，其中 F-NaF 摄取是最强的预测因子。
