Cooper Medical School of Rowan University, 401 S. Broadway, Camden, NJ 08103, USA.
Clement J Zablocki Veterans Hospital, Medical College of Wisconsin, 5000 W. National Ave., Milwaukee, WI, USA.
Best Pract Res Clin Rheumatol. 2021 Dec;35(4):101718. doi: 10.1016/j.berh.2021.101718. Epub 2021 Oct 22.
Calcium pyrophosphate deposition disease is defined by the presence of calcium pyrophosphate (CPP) crystals in articular cartilage and is the fourth most common type of arthritis in adults. Despite its high prevalence, the etiology of CPPD disease remains unclear and no specific therapies currently exist. It has been known for several decades that abnormalities of cartilage pyrophosphate metabolism are common in patients with CPPD disease, and this classic work will be reviewed here. Recent studies of rare familial forms of CPPD disease have provided additional novel information about its pathophysiology. This work suggests that CPPD disease occurs through at least two unique and potentially intertwined biomolecular pathways. We are hopeful that a detailed understanding of the components and regulation of these pathways will lead to improved therapies for this common disease.
焦磷酸钙沉积病是由关节软骨中存在焦磷酸钙（CPP）晶体定义的，是成年人中第四种最常见的关节炎。尽管其发病率很高，但 CPPD 病的病因仍不清楚，目前也没有特定的治疗方法。几十年来，人们已经知道，患有 CPPD 病的患者软骨焦磷酸盐代谢异常很常见，这里将对此经典研究进行综述。最近对 CPPD 病罕见家族形式的研究为其病理生理学提供了更多新信息。这项工作表明，CPPD 病至少通过两种独特且可能相互交织的生物分子途径发生。我们希望对这些途径的组成和调节有更详细的了解，将为这种常见疾病带来更好的治疗方法。
