激肽释放酶 11 在乳腺癌中的下调：与预后参数的相关性。
Kallikrein 11 Down-regulation in Breast Carcinoma: Correlation With Prognostic Parameters.
机构信息
Department of Pathology, Cerrahpasa Medical School, Istanbul University Cerrahpasa, Istanbul, Turkey;
Department of Pathology, Cerrahpasa Medical School, Istanbul University Cerrahpasa, Istanbul, Turkey.
出版信息
In Vivo. 2021 Nov-Dec;35(6):3233-3243. doi: 10.21873/invivo.12618.
BACKGROUND
Expression of kallikrein-11 (KLK11) has been found to be related to the prognosis of various human cancer types but its physiological functions in the steps of breast cancer (BC) progression are still unknown.
MATERIALS AND METHODS
BC and adjacent normal breast tissue samples were collected from 28 patients. KLK11 expression levels were determined by real-time polymerase chain reaction for each sample and associations with known prognostic features were statistically analyzed.
RESULTS
Although there was slight up-regulation in tumor tissues overall, significant down-regulation of KLK11 expression in tumor tissue was observed in the elderly and in patients with perineural invasion. Furthermore, tumor size, grade, mitotic score, necrosis, calcification, lymphatic invasion, hormone receptor status and Ki67 expression were associated with altered KLK11 level.
CONCLUSION
Changes in expression levels of KLK11, associated with patient characteristics, might be used as complementary data in order to predict clinical outcome and prognosis in BC.
背景
激肽释放酶 11（KLK11）的表达与多种人类癌症类型的预后有关，但它在乳腺癌（BC）进展过程中的生理功能尚不清楚。
材料与方法
收集了 28 名患者的 BC 和相邻正常乳腺组织样本。通过实时聚合酶链反应（PCR）确定每个样本中的 KLK11 表达水平，并对其与已知预后特征进行统计学分析。
结果
尽管总体上肿瘤组织略有上调，但在老年患者和神经周围侵犯患者的肿瘤组织中观察到 KLK11 表达明显下调。此外，肿瘤大小、分级、有丝分裂评分、坏死、钙化、淋巴管浸润、激素受体状态和 Ki67 表达与 KLK11 水平的改变有关。
结论
与患者特征相关的 KLK11 表达水平的变化，可作为补充数据，用于预测 BC 的临床结局和预后。
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