Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Gunma University Heavy Ion Medical Center, Maebashi, Japan.
In Vivo. 2021 Nov-Dec;35(6):3521-3526. doi: 10.21873/invivo.12654.
BACKGROUND/AIM: Auto-activation positron emission tomography (AAPET) is one of the most promising methods to verify beam range in carbon ion radiotherapy (C-ion RT). We aimed to confirm this for the first time in a clinical setting by performing AAPET in a patient with pancreatic cancer previously receiving coil embolisation of hepatic artery pseudoaneurysm.
A 70-year-old pancreatic head cancer patient was treated with C-ion RT on a clinical dose of 4.6 Gy (RBE), followed by AAPET, to verify beam ranges in C-ion RT.
Positron emission tomography (PET) revealed low positron emitter concentrations at the distal side of the internal metals and in the aorta compared to the dose distribution of the treatment plan, indicating range shortening by internal metals in C-ion beams and positron emitter transportation by biofluids.
AAPET may detect range shortening by internal metals in the trajectory and washout of intravascular positron emitter compared to plan dose distribution.
背景/目的：自动激活正电子发射断层扫描（AAPET）是验证碳离子放射治疗（C-ion RT）中射束范围的最有前途的方法之一。我们旨在通过对先前接受肝动脉假性动脉瘤线圈栓塞治疗的胰腺癌患者进行 AAPET，首次在临床环境中证实这一点。
对一名 70 岁的胰头癌患者进行 C-ion RT 治疗，采用临床剂量 4.6 Gy（RBE），然后进行 AAPET，以验证 C-ion RT 中的射束范围。
与治疗计划的剂量分布相比，正电子发射断层扫描（PET）显示远端内部金属和主动脉的正电子发射体浓度较低，表明 C 离子束内金属导致射程缩短和生物流体中的正电子发射体运输。
与计划剂量分布相比，AAPET 可检测到轨迹内金属导致的射程缩短和血管内正电子发射体的洗脱。
