Pennsylvania State University College of Medicine- Hershey Medical Center, Hershey, PA, USA.
Handb Exp Pharmacol. 2022;272:39-52. doi: 10.1007/164_2021_556.
Antiproliferative agents include Mycophenolic acid and Azathioprine (which is less commonly used unless in certain conditions). They were initially identified for use in autoimmune and cancer research due to their role in disruption of cellular replication. They have now become the cornerstone of antirejection maintenance therapy in solid organ transplant. In this chapter we will describe the major times that lead to discovery, mechanisms of action, side effects, use during pregnancy and the major clinical trials.
抗增殖剂包括霉酚酸和硫唑嘌呤（除非在某些情况下，否则较少使用）。由于它们在破坏细胞复制中的作用，最初被确定用于自身免疫和癌症研究。现在，它们已成为实体器官移植中抗排斥维持治疗的基石。在本章中，我们将描述导致发现的主要时期、作用机制、副作用、妊娠期间的使用以及主要临床试验。
