钛纳米结构表面的各种变体与从脂肪组织中分离出的间充质干细胞的相互作用。

Interaction of Various Variants of the Nanostructured Surface of Titanium with MSCs Isolated from Adipose Tissue.

作者信息

Gosteva Ekaterina A, Dymnikov Alexander B, Starkov Vitaliy V, Sedlovets Daria M, Valikhov Marat P, Vishnevsky Dmytryi A, Chekhonin Vladimir P, Tumanyan Gurgen A, Ahmad Masound K

机构信息

Department of the Material Science of Semiconductors and Dielectrics, National University of Science and Technology MISiS, 4 Leninskiy Prospekt, 119049 Moscow, Russia.

Academy of Engineering, RUDN University, 117198 Moscow, Russia.

出版信息

Biomimetics (Basel). 2021 Oct 18;6(4):61. doi: 10.3390/biomimetics6040061.

DOI:10.3390/biomimetics6040061

PMID:34698073

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8544202/

Abstract

Titanium has been successfully used in dental implantology for a long time. Due to the osseointegration process, titanium implants are able to withstand the chewing load. This article is devoted to the study of surface treatment methods of titanium alloys and the study of their interaction with mesenchymal stem cells (MSCs). The surface microrelief can influence MSC differentiation in different ways, which subsequently gives it osteogenic potential. The paper proposes modes of surface modification of titanium alloys on Grade 4 and Grade 1 by chemical and electrochemical (anodizing) etching. The possibility of modifying the surface of titanium alloys using the synthesis of graphene layers has been proposed in this paper for the first time. The osteogenic potential of a particular surface was assessed by the number of mesenchymal stem cells cultured on them under identical conditions.

摘要

长期以来，钛已成功应用于牙种植学领域。由于骨整合过程，钛植入物能够承受咀嚼负荷。本文致力于研究钛合金的表面处理方法及其与间充质干细胞（MSCs）相互作用的研究。表面微观形貌可以通过不同方式影响MSCs的分化，进而赋予其成骨潜力。本文提出了通过化学和电化学（阳极氧化）蚀刻对4级和1级钛合金进行表面改性的方式。本文首次提出了利用石墨烯层合成来改性钛合金表面的可能性。通过在相同条件下培养在特定表面上的间充质干细胞数量来评估其成骨潜力。