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爱尔兰养老院中抗精神病药物处方的流行情况及记录在案的用药指征

The Prevalence of and Documented Indications for Antipsychotic Prescribing in Irish Nursing Homes.

作者信息

Kelleher Jayne E, Weedle Peter, Donovan Maria D

机构信息

Peter Weedle Allcare Pharmacy, P51HCP4 Cork, Ireland.

Pharmaceutical Care Research Group, School of Pharmacy, University College Cork, T12YN60 Cork, Ireland.

出版信息

Pharmacy (Basel). 2021 Sep 30;9(4):160. doi: 10.3390/pharmacy9040160.

Abstract

BACKGROUND

Antipsychotic medications are often used 'off-licence' to treat neuropsychiatric symptoms and disorders of aging and to manage behavioural and psychological symptoms of dementia despite the warnings of adverse effects.

OBJECTIVE

To establish the prevalence of and documented indication for antipsychotic medication use in the Irish nursing home setting.

SETTING

This study was conducted in six nursing homes located in Co. Cork, Ireland.

METHOD

A retrospective, cross-sectional study was employed. All patients who met the inclusion criteria (≥65 years, residing in a nursing home on a long-term basis) were eligible for inclusion. There were 120 nursing home residents recruited to the study.

MAIN OUTCOME MEASURE

The prevalence of antipsychotic medication use in nursing home residents (with and without dementia).

RESULTS

The overall prevalence of antipsychotic prescribing was found to be 48% and patients with dementia were significantly more likely to be prescribed an antipsychotic compared to those without dementia (67% vs. 25%) (χ (1, = 120) = 21.541, < 0.001). In the cohort of patients with dementia, there was a trend approaching significance ( = 0.052) of decreasing antipsychotic use with increasing age (age 65-74 = 90%; age 75-84 = 71%; age 85 and over = 58%). An indication was documented for 84% of the antipsychotic prescriptions in this cohort.

CONCLUSIONS

The findings of this study highlight that high rates of antipsychotic medication use remains an issue in Irish nursing homes. Further work should explore factors in influencing prescribing of these medications in such settings.

摘要

背景

尽管有关于副作用的警告,但抗精神病药物经常被“超适应证”用于治疗神经精神症状、衰老相关疾病以及管理痴呆患者的行为和心理症状。

目的

确定爱尔兰养老院环境中抗精神病药物使用的患病率及记录在案的用药指征。

设置

本研究在爱尔兰科克郡的六家养老院进行。

方法

采用回顾性横断面研究。所有符合纳入标准(≥65岁,长期居住在养老院)的患者均有资格纳入。共有120名养老院居民被纳入该研究。

主要观察指标

养老院居民(患有和未患有痴呆症)中抗精神病药物的使用患病率。

结果

发现抗精神病药物处方的总体患病率为48%,与未患痴呆症的患者相比,患痴呆症的患者更有可能被开具抗精神病药物(67%对25%)(χ(1, = 120) = 21.541,<0.001)。在痴呆症患者队列中,随着年龄增长,抗精神病药物使用有下降趋势(= 0.052)(65 - 74岁 = 90%;75 - 84岁 = 71%;85岁及以上 = 58%)。该队列中84%的抗精神病药物处方记录了用药指征。

结论

本研究结果突出表明,抗精神病药物的高使用率在爱尔兰养老院中仍然是一个问题。进一步的工作应探索在此类环境中影响这些药物处方的因素。

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