Rana Roberta, Perrillo Teresa, Santoro Nicola, Ortolani Federica, Messina Raffaella, Resta Mariachiara, Perrucci Ilenia, Ingravallo Giuseppe, Cazzato Gerardo, Grassi Massimo, Pesce Sabino, Signorelli Francesco
Department of Pediatric Oncology and Hematology, University "Aldo Moro" of Bari, 70124 Bari, Italy.
Department of Metabolic Diseases, Clinical Genetics and Diabetology, Giovanni XXIII Children's Hospital, 70124 Bari, Italy.
Neurol Int. 2021 Oct 20;13(4):535-540. doi: 10.3390/neurolint13040053.
Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparency in reporting the synthesis of qualitative research) framework. A search was made in MEDLINE/Pubmed and MeSH Database using the terms "precocious puberty" AND "brain tumor" OR "posterior fossa tumor" OR "cerebellar tumor" OR "infratentorial tumor", identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic-pituitary-gonadal axis involvement and/or intracranial hypertension. Our work highlights the importance of a multidisciplinary approach and extensive central nervous system imaging for patients presenting with CPP in order to detect possible tumor association. Moreover, we believe that this manuscript could contribute to stimulate other research because the exact mechanism of CPP in infratentorial brain lesions has not been understood yet.
中枢性性早熟（CPP）是一种导致早期促性腺激素依赖性性发育的病症；在大多数情况下，女童的CPP为特发性，而超过50%的男童有可查明的病因。我们按照ENTREQ（提高定性研究综合报告的透明度）框架进行了一项定性系统评价。在MEDLINE/Pubmed和医学主题词表数据库中使用“性早熟”和“脑肿瘤”或“后颅窝肿瘤”或“小脑肿瘤”或“幕下肿瘤”进行检索，确定了5例患有幕下肿瘤和CPP的儿科患者，以及1例无下丘脑 - 垂体 - 性腺轴受累和/或颅内高压的小脑神经节胶质瘤病例。我们的工作强调了多学科方法和对患有CPP的患者进行广泛中枢神经系统成像以检测可能的肿瘤关联的重要性。此外，我们认为这篇手稿可能有助于激发其他研究，因为幕下脑病变中CPP的确切机制尚未明确。
