Department of Obstetrics and Gynecology, Ufuk University, Ankara, Turkey.
Private Gynecology and Obstetrics Clinic, Ankara, Turkey.
J Obstet Gynaecol. 2022 Jul;42(5):1319-1324. doi: 10.1080/01443615.2021.1962819. Epub 2021 Oct 26.
Patients with polycystic ovary syndrome display increased levels of anti-Müllerian hormone. Frozen-thawed embryo transfer (FET) prevents ovarian hyperstimulation and results in better pregnancy outcome in PCOS patients. Therefore, we aimed to evaluate the effect of serum AMH levels on the pregnancy outcome of FET cycles in PCOS patients. 110 infertile women with PCOS who were recommended for embryo cryopreservation followed by FET. The patients' AMH levels were evaluated, and the age-related AMH percentiles were determined. The patients were then grouped according to AMH percentiles, namely, 75th-90th percentile (Group 1) and higher than the 90th percentile (Group 2).A total of 110 PCOS patients who conceived in Frozen Embryo Transfer (FET)-In-vitro Fertilisation (IVF) cycles were included in this study. The preterm delivery rates in FET cycles were higher in the group of PCOS patients with AMH levels greater than the 90th percentile than in patients in the 75th-90th percentile group (50% vs 28.8%, = .024). In conclusion, PCOS patients with AMH levels higher than the 90 percentile had substantially higher preterm delivery rates than those with AMH levels at the 75-90 percentile, suggesting the need for closer follow-up. Further studies are needed to elucidate the underlying mechanisms behind this correlation.IMPACT STATEMENT The association of AMH levels with the risk of adverse pregnancy outcomes has been previously investigated. In women with PCOS, substantially elevated AMH levels were significantly associated with preterm birth. Results showed that the PCOS patients with higher AMH levels and underwent assisted reproductive treatment demonstrated an increased risk of preterm labour than the PCOS patients with lower AMH levels. In women with PCOS, substantially elevated AMH levels were significantly related to preterm birth, suggesting the need for closer follow-up in this population and the need for further studies to elucidate the underlying mechanisms behind this correlation.
多囊卵巢综合征患者的抗苗勒管激素水平升高。冻融胚胎移植（FET）可防止卵巢过度刺激，并改善 PCOS 患者的妊娠结局。因此，我们旨在评估血清 AMH 水平对 PCOS 患者 FET 周期妊娠结局的影响。110 名建议胚胎冷冻保存后行 FET 的多囊卵巢综合征不孕患者。评估患者的 AMH 水平，并确定与年龄相关的 AMH 百分位数。然后根据 AMH 百分位数将患者分组，即 75-90 百分位（第 1 组）和高于 90 百分位（第 2 组）。本研究共纳入 110 例接受冻融胚胎移植（FET）-体外受精（IVF）周期妊娠的多囊卵巢综合征患者。第 2 组（AMH 水平大于 90 百分位）的 FET 周期早产率高于第 1 组（75-90 百分位）（50%比 28.8%，=0.024）。结论：AMH 水平高于 90 百分位的 PCOS 患者的早产率明显高于 AMH 水平在 75-90 百分位的患者，提示需要密切随访。需要进一步的研究来阐明这种相关性的潜在机制。
意义陈述： 先前已经研究了 AMH 水平与不良妊娠结局风险之间的关联。在 PCOS 患者中，AMH 水平显著升高与早产显著相关。结果表明，接受辅助生殖治疗的 AMH 水平较高的 PCOS 患者与 AMH 水平较低的 PCOS 患者相比，早产的风险增加。在 PCOS 患者中，AMH 水平显著升高与早产显著相关，提示在该人群中需要密切随访，并需要进一步研究来阐明这种相关性的潜在机制。
