Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Department of Molecular Medicine, Birjand University of Medical Sciences, Birjand, Iran.
J Obstet Gynaecol. 2022 Jul;42(5):1352-1357. doi: 10.1080/01443615.2021.1965103. Epub 2021 Oct 26.
Human leukocyte antigen-G (HLA-G) has immune-modulatory functions. Although the role of genetic variant HLA-G (rs1063320) in susceptibility to human papillomavirus (HPV) infection has been widely considered, it is still a matter of discussion. In order to shed light on the issue, we, therefore, conducted a meta-analysis to evaluate the common impact of the HLA-G (rs1063320) variant on susceptibility to HPV infection. Subsequently, the distribution of genotypes, genotyping techniques and ethnicity groups was collected, and general analyses were performed. A total number of five studies with 953 cases and 877 controls were found to meet our criteria. The polymorphism of HLA-G (rs1063320) was evaluated. This is the first meta-analysis to explore the connection between the HLA-G 3' UTR + 3142C/G (rs1063320) genetic variant and the risk of HPV infection. Our results showed no association between the variant of HLA-G 3' UTR + 3142C/G (rs1063320) and susceptibility to HPV infection in studied target populations.Impact Statement Human papillomavirus (HPV) is the most widespread sexually transmitted infection in both men and women all over the world. It is correlated with prominent load of diseases and malignancies, including anogenital warts and anogenital and oropharyngeal cancers. In recent years, several studies manifested that different SNPs located on special genes seems to influence HPV infection risk. Our findings disclosed no relation between the variant of HLA-G 3' UTR + 3142C/G (rs1063320) and vulnerability to HPV infection in the target individuals. The findings in current survey may offer a basis for further study on HLA-G variant in future investigation.
人类白细胞抗原-G（HLA-G）具有免疫调节功能。虽然遗传变异 HLA-G（rs1063320）在易感性人乳头瘤病毒（HPV）感染中的作用已被广泛研究，但仍存在争议。因此，为了阐明这一问题，我们进行了荟萃分析，以评估 HLA-G（rs1063320）变异与 HPV 感染易感性的常见影响。随后，收集了基因型、基因分型技术和种族群体的分布情况，并进行了综合分析。共有五项研究符合我们的标准，共纳入 953 例病例和 877 例对照。评估了 HLA-G（rs1063320）的多态性。这是第一项探讨 HLA-G 3'UTR+3142C/G（rs1063320）遗传变异与 HPV 感染风险之间关系的荟萃分析。我们的研究结果表明，在研究的目标人群中，HLA-G 3'UTR+3142C/G（rs1063320）变异与 HPV 感染易感性之间没有关联。
HPV 是全球男性和女性最常见的性传播感染。它与显著的疾病和恶性肿瘤负担有关，包括生殖器疣和生殖器和口咽癌。近年来，多项研究表明，位于特定基因上的不同 SNP 似乎会影响 HPV 感染风险。我们的研究结果表明，在目标人群中，HLA-G 3'UTR+3142C/G（rs1063320）变异与 HPV 感染易感性之间没有关系。本研究中的发现可能为未来进一步研究 HLA-G 变异提供依据。
