Turku University Hospital, University of Turku, Turku, Finland.
Department of Obstetrics and Gynecology, Kymenlaakso Central Hospital, Kotkantie 41, 48210, Kotka, Finland.
BMC Infect Dis. 2021 May 4;21(1):419. doi: 10.1186/s12879-021-06079-7.
Human leukocyte antigen (HLA)-G may have an important role in the natural history of human papillomavirus (HPV) infection. Our aim was to evaluate the role of HLA-G in the outcome of genital and oral HPV infections in women.
Analyses included 306 women from the Finnish Family HPV-study and were followed-up for six years. Genital and oral samples were tested for 24 different HPV types with multiplex HPV genotyping. HLA-G alleles were determined through direct DNA-sequencing. Unconditional logistic regression was used to determine the associations between HLA-G genotypes and HPV infection outcomes.
Ten HLA-G alleles were identified. Most common HLA-G genotypes were the wild type G01:01:01/01:01:01 (31.3%) followed by G01:01:01/01:01:02 (26.8%). G01:01:01/01:01:01 genotype was associated with increased risk of oral HPV infections by any HPV type or single-type with OR = 1.86 (95% CI 1.14-3.04, P = 0.01) and 2.22 (95% CI 1.14-3.71, P = 0.02), respectively. G04:01+ allele and the G01:01:01/01:04:01 genotype both protected from any and single oral HPV infections; OR = 0.46 (95% CI 0.23-0.89, P = 0.02) and 0.53 (95% CI 0.23-0.97, P = 0.03), respectively. G01:01:02/01:04:01 genotype increased significantly the risk of infertility and its treatments, with respective OR = 5.06 (95% CI 1.22-21.02, P = 0.03) and OR = 9.07 (95% CI 1.22-39.50, P = 0.03). Both HLA-G alleles and genotypes showed several significant associations with the outcomes of oral HPV infections, but none of them had any impact on the outcomes of genital HPV infections in these women.
The host HLA-G genotypes appear to impact the outcomes of oral HPV infections in women but have little if any effect on genital HPV status or infection outcomes.
人类白细胞抗原（HLA）-G 可能在人类乳头瘤病毒（HPV）感染的自然史中发挥重要作用。我们的目的是评估 HLA-G 在女性生殖器和口腔 HPV 感染结局中的作用。
分析包括来自芬兰家庭 HPV 研究的 306 名女性，随访时间为 6 年。使用多重 HPV 基因分型对 24 种不同的 HPV 类型进行生殖器和口腔样本检测。通过直接 DNA 测序确定 HLA-G 等位基因。使用非条件逻辑回归来确定 HLA-G 基因型与 HPV 感染结局之间的关联。
确定了 10 种 HLA-G 等位基因。最常见的 HLA-G 基因型是野生型 G01:01:01/01:01:01（31.3%），其次是 G01:01:01/01:01:02（26.8%）。G01:01:01/01:01:01 基因型与任何 HPV 类型或单一类型的口腔 HPV 感染风险增加相关，OR 值分别为 1.86（95%CI 1.14-3.04，P=0.01）和 2.22（95%CI 1.14-3.71，P=0.02）。G04:01+ 等位基因和 G01:01:01/01:04:01 基因型均能预防任何和单一的口腔 HPV 感染；OR 值分别为 0.46（95%CI 0.23-0.89，P=0.02）和 0.53（95%CI 0.23-0.97，P=0.03）。G01:01:02/01:04:01 基因型显著增加了不孕及其治疗的风险，相应的 OR 值分别为 5.06（95%CI 1.22-21.02，P=0.03）和 9.07（95%CI 1.22-39.50，P=0.03）。HLA-G 等位基因和基因型均与口腔 HPV 感染结局有显著关联，但在这些女性中，它们均未对生殖器 HPV 感染的结局产生任何影响。
宿主 HLA-G 基因型似乎影响女性口腔 HPV 感染的结局，但对生殖器 HPV 状态或感染结局的影响很小或没有影响。
