Font Marc, Gulías Moisés, Mascareñas José Luis
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Angew Chem Int Ed Engl. 2022 Feb 1;61(6):e202112848. doi: 10.1002/anie.202112848. Epub 2021 Dec 2.
The selective functionalization of C(sp )-H bonds using transition-metal catalysis is among the more attractive transformations of modern synthetic chemistry. In addition to its inherent atom economy, such reactions open unconventional retrosynthetic pathways that can streamline synthetic processes. However, the activation of intrinsically inert C(sp )-H bonds, and the selection among very similar C-H bonds, represent highly challenging goals. In recent years there has been notable progress tackling these issues, especially with regard to the development of intermolecular reactions entailing the formation of C-C and C-heteroatom bonds. Conversely, the assembly of cyclic products from simple acyclic precursors using metal-catalyzed C(sp )-H bond activations has been less explored. Only recently has the number of reports on such annulations started to grow. Herein we give an overview of some of the more relevant advances in this exciting topic.
利用过渡金属催化实现C(sp³)-H键的选择性官能团化是现代合成化学中较具吸引力的转化反应之一。除了其固有的原子经济性外，此类反应还开辟了非常规的逆合成途径，可简化合成过程。然而，激活本质上惰性的C(sp³)-H键以及在非常相似的C-H键之间进行选择是极具挑战性的目标。近年来，在解决这些问题方面取得了显著进展，特别是在涉及形成C-C键和C-杂原子键的分子间反应的开发方面。相反，使用金属催化的C(sp³)-H键活化从简单的无环前体组装环状产物的研究较少。直到最近，关于此类环化反应的报道数量才开始增加。在此，我们概述了这一令人兴奋的主题中一些较为相关的进展。
