Dermatology & Venereology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Department of Dermatology and Venereology, Armed Forces College of Medicine, Tanta, Egypt.
J Cosmet Dermatol. 2022 Jul;21(7):2817-2825. doi: 10.1111/jocd.14538. Epub 2021 Oct 26.
Melasma is a common acquired symmetrically distributed hyperpigmented macules of sun-exposed skin. Skin microneedling acts as a transdermal delivery system that facilitates the penetration of lightening agents to deeper layers of skin.
Clinical and dermoscopic evaluation of the efficacy and safety of topical tranexamic acid versus topical vitamin C after microneedling for melasma treatment.
Twenty patients with facial melasma were enrolled in a split-face prospective, randomized uncontrolled study. The right side of the face was treated with topical tranexamic acid after dermapen microneedling, while the left side of the face was treated with topical vitamin C after dermapen microneedling. Sessions were done every 2 weeks for 6 sessions. The Hemi-MASI score and dermoscopic examination before and after treatment were done.
Hemi-MASI score was reduced after treatment on both sides of the face, besides improvement of the pigmented lesions showed by dermoscopy on both sides and improvement of the vascular component on the tranexamic acid treated side.
Topical tranexamic acid or vitamin C application after dermapen microneedling was an effective and safe technique in melasma treatment with minimal side effects, and vascular component improvement by tranexamic acid.
黄褐斑是一种常见的获得性、对称性分布于日光暴露部位的皮肤色素沉着斑。皮肤微针作用为一个经皮传递系统，促进美白剂渗透到皮肤的更深层。
评估微针后局部给予氨甲环酸与维生素 C 治疗黄褐斑的疗效和安全性。
20 例面部黄褐斑患者纳入一项分割面部前瞻性、随机对照非治疗研究。微针后右侧面部给予局部氨甲环酸治疗，左侧面部给予局部维生素 C 治疗。每 2 周治疗 1 次，共 6 次。治疗前后进行 Hemi-MASI 评分和皮肤镜检查。
面部两侧治疗后 Hemi-MASI 评分均降低，皮肤镜下两侧色素斑改善，氨甲环酸治疗侧血管成分改善。
微针后局部给予氨甲环酸或维生素 C 是一种安全有效的治疗黄褐斑的方法，副作用小，氨甲环酸可改善血管成分。
