Dermatology Department, Ministry of Health, Benha University, Benha, Egypt.
Professor of Dermatology and Venereology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Arch Dermatol Res. 2024 Oct 5;316(9):662. doi: 10.1007/s00403-024-03355-9.
Several treatment modalities have been used for the treatment of melasma. Topical metformin is an anti-diabetic drug, which has melanopenic action. Vitamin C acts on melanin by inhibiting the tyrosinase enzyme, thus inhibiting melanogenesis. To compare the efficacy and safety of microneedling combined with topical metformin solution versus microneedling combined with topical vitamin C in the treatment of melasma. A spitted-face interventional comparative on 30 female patients suffering from melasma. The right side of the face was treated with microneedling and topical metformin, while the left side was treated with microneedling and topical vitamin C solution. Hemi-MASI score decreased significantly after treatment from before treatment in both groups P-value < 0.001. The percentage of improvement of Hemi-MASI score metformin group was 48.29%, While with vitamin C group was 37.19%. There was a significant improvement in dermoscopic findings in microneedling with topical metformin than with topical vitamin C group. Microneedling with topical metformin or topical vitamin C solution can be an effective and safe therapeutic option for treating melasma with no significant side effects.
已有多种治疗方法用于治疗黄褐斑。局部二甲双胍是一种抗糖尿病药物，具有黑色素减少作用。维生素 C 通过抑制酪氨酸酶来作用于黑色素，从而抑制黑色素生成。比较微针联合局部二甲双胍溶液与微针联合局部维生素 C 治疗黄褐斑的疗效和安全性。一项涉及 30 名患有黄褐斑的女性患者的裂面干预性比较研究。面部右侧接受微针和局部二甲双胍治疗，左侧接受微针和局部维生素 C 溶液治疗。两组治疗后 Hemi-MASI 评分均较治疗前显著下降（P 值均<0.001）。二甲双胍组 Hemi-MASI 评分改善率为 48.29%，而维生素 C 组为 37.19%。与维生素 C 组相比，局部使用二甲双胍的微针治疗在皮肤镜下的发现有明显改善。微针联合局部二甲双胍或局部维生素 C 溶液治疗黄褐斑是一种有效且安全的治疗选择，无明显副作用。
