Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Biomed Pharmacother. 2021 Dec;144:112292. doi: 10.1016/j.biopha.2021.112292. Epub 2021 Oct 23.
The centrosome is a special organelle in human cells and an organizing unit for microtubules and signaling molecules. In addition, the centrosome is tightly restricted during the cell cycle and forms the basal body of the cilia in ciliated cells. Centrosome abnormality is frequently observed in malignant tumors. The dysregulation of centrosome-associated proteins leads to multipolar mitosis, aneuploidy, and nondirected cell migration, and therefore promotes cancer progression. The overduplication of primary centrosome and the accumulation of chromosome, comprise the majority cause of chromosomal mis-segregation in cancer cells. This review discusses the structure and function of the centrosome and the role of its associated proteins in the progression of solid tumors. We summarized the effects of centrosome amplification abnormalities and other centrosome-related phenotypes on tumors. The mechanism of the delineation of centrosome amplification with tumor malignancy remains to be decided. A better understanding of centrosome abnormality in tumorigenesis may be useful to screen novel therapeutic strategies for the treatment of solid tumors.
中心体是人类细胞中的一种特殊细胞器，也是微管和信号分子的组织单元。此外，中心体在细胞周期中受到严格限制，并在纤毛细胞中形成纤毛的基体。中心体异常在恶性肿瘤中经常观察到。中心体相关蛋白的失调导致多极有丝分裂、非整倍体和无定向细胞迁移，从而促进癌症进展。初级中心体的过度复制和染色体的积累，是癌细胞中染色体错误分离的主要原因。本综述讨论了中心体的结构和功能以及其相关蛋白在实体瘤进展中的作用。我们总结了中心体扩增异常和其他与中心体相关的表型对肿瘤的影响。中心体扩增与肿瘤恶性程度的关系的机制仍有待确定。更好地了解肿瘤发生过程中的中心体异常可能有助于筛选治疗实体瘤的新型治疗策略。
