van Ree Janine H, Nam Hyun-Ja, van Deursen Jan M
Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
Chromosome Res. 2016 Jan;24(1):67-76. doi: 10.1007/s10577-015-9501-9.
Centrosomes are microtubule-organizing centers that duplicate in S phase to form bipolar spindles that separate duplicated chromosomes faithfully into two daughter cells during cell division. Recent studies show that proper timing of centrosome dynamics, the disjunction and movement of centrosomes, is tightly linked to spindle symmetry, correct microtubule-kinetochore attachment, and chromosome segregation. Here, we review mechanisms that regulate centrosome dynamics, with emphasis on the roles of key mitotic kinases in the proper timing of centrosome dynamics and how aberrancies in these processes may cause chromosomal instability and cancer.
中心体是微管组织中心，在S期进行复制以形成双极纺锤体，在细胞分裂期间将复制后的染色体准确地分离到两个子细胞中。最近的研究表明，中心体动力学的正确时间安排，即中心体的分离和移动，与纺锤体对称性、正确的微管-动粒附着以及染色体分离密切相关。在这里，我们综述调节中心体动力学的机制，重点关注关键有丝分裂激酶在中心体动力学正确时间安排中的作用，以及这些过程中的异常如何导致染色体不稳定和癌症。
