二酰基甘油和佛波酯对小鼠神经肌肉接头处乙酰胆碱释放及作用的影响。
Effects of diacylglycerol and phorbol ester on acetylcholine release and action at the neuromuscular junction in mice.
作者信息
Murphy R L, Smith M E
出版信息
Br J Pharmacol. 1987 Feb;90(2):327-34. doi: 10.1111/j.1476-5381.1987.tb08962.x.
Abstract
Miniature endplate potentials and nerve-evoked endplate potentials were studied in a phrenic nerve-diaphragm preparation of the mouse. A phorbol ester, phorbol-12 beta, 13 alpha-dibutyrate, and a diacylglycerol, 1-oleyl-2-acetyl-sn-glycerol, both increased the frequency of miniature endplate potentials. The effect of the phorbol ester on the frequency was still significant when the preparation was incubated in a calcium-deficient solution. The phorbol ester, but not the diacylglycerol, caused a significant increase in the amplitude of the miniature potentials. The phorbol ester also increased the amplitude of the endplate potentials in the presence of (+)-tubocurarine. The mechanisms of action of phorbol ester and diacylglycerol are discussed in relation to the control of acetylcholine release and action at the neuromuscular junction.
摘要
在小鼠膈神经 - 膈肌标本中研究了微小终板电位和神经诱发的终板电位。佛波酯（佛波醇 - 12β，13α - 二丁酸酯）和二酰基甘油（1 - 油酰基 - 2 - 乙酰基 - sn - 甘油）均增加了微小终板电位的频率。当标本在缺钙溶液中孵育时，佛波酯对频率的影响仍然显著。佛波酯而非二酰基甘油使微小电位的幅度显著增加。在存在（+） - 筒箭毒碱的情况下，佛波酯也增加了终板电位的幅度。结合乙酰胆碱释放的控制以及在神经肌肉接头处的作用，讨论了佛波酯和二酰基甘油的作用机制。
相似文献
1
Effects of diacylglycerol and phorbol ester on acetylcholine release and action at the neuromuscular junction in mice.二酰基甘油和佛波酯对小鼠神经肌肉接头处乙酰胆碱释放及作用的影响。
Br J Pharmacol. 1987 Feb;90(2):327-34. doi: 10.1111/j.1476-5381.1987.tb08962.x.
2
Effects of sodium selenite on neuromuscular junction of the mouse phrenic nerve-diaphragm preparation.亚硒酸钠对小鼠膈神经 - 膈肌标本神经肌肉接头的影响。
Neuropharmacology. 1989 Jul;28(7):733-9. doi: 10.1016/0028-3908(89)90159-7.
3
Activation of protein kinase C increases acetylcholine release from frog motor nerves by a direct action on L-type Ca(2+) channels and apparently not by depolarisation of the terminal.蛋白激酶C的激活通过直接作用于L型钙通道增加青蛙运动神经中乙酰胆碱的释放，且显然不是通过终末去极化实现的。
Neuroscience. 2001;104(4):1157-64. doi: 10.1016/s0306-4522(01)00114-2.
4
Run-down of neuromuscular transmission during repetitive nerve activity by nicotinic antagonists is not due to desensitization of the postsynaptic receptor.烟碱样拮抗剂在重复神经活动期间导致的神经肌肉传递减弱并非由于突触后受体脱敏。
Br J Pharmacol. 1991 Apr;102(4):817-22. doi: 10.1111/j.1476-5381.1991.tb12258.x.
5
Phorbol ester- and diacylglycerol-mediated desensitization of cardiac beta-adrenergic receptors.
Circ Res. 1985 Sep;57(3):443-9. doi: 10.1161/01.res.57.3.443.
6
Modulation of Ca(2+)-dependent and Ca(2+)-independent miniature endplate potentials by phorbol ester and adenosine in frog.佛波酯和腺苷对青蛙中钙依赖性和非钙依赖性微小终板电位的调节作用
Br J Pharmacol. 2005 Aug;145(7):954-62. doi: 10.1038/sj.bjp.0706248.
7
[Effect of tubocurarine on the quantum release of acetylcholine during the infrequent stimulation of a motor nerve].[筒箭毒碱对运动神经低频刺激期间乙酰胆碱量子释放的影响]
Fiziol Zh SSSR Im I M Sechenova. 1988 Oct;74(10):1377-82.
8
1,2-Didecanoylglycerol and phorbol 12,13-dibutyrate enhance anterior pituitary hormone secretion in vitro.1,2 - 二癸酰甘油和佛波醇12,13 - 二丁酸酯在体外可增强垂体前叶激素的分泌。
Endocrinology. 1985 Oct;117(4):1559-64. doi: 10.1210/endo-117-4-1559.
9
1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.1,2 - 二酰甘油和佛波酯抑制激动剂诱导的人血小板中肌醇磷酸的形成：对肌醇磷脂水解负反馈调节的可能影响。
Proc Natl Acad Sci U S A. 1985 May;82(9):2623-6. doi: 10.1073/pnas.82.9.2623.
10
Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner.蛋白激酶C激活剂以百日咳毒素敏感的方式选择性增强培养的感觉神经元钙电流成分的失活。
J Neurophysiol. 1989 Jun;61(6):1259-69. doi: 10.1152/jn.1989.61.6.1259.
引用本文的文献
1
Activation of presynaptic 5-hydroxytryptamine 2A receptors facilitates excitatory synaptic transmission via protein kinase C in the dorsolateral septal nucleus.突触前5-羟色胺2A受体的激活通过蛋白激酶C促进背外侧隔核中的兴奋性突触传递。
J Neurosci. 2002 Sep 1;22(17):7509-17. doi: 10.1523/JNEUROSCI.22-17-07509.2002.
2
The structural requirements for phorbol esters to enhance serotonin and acetylcholine release from rat brain cortex.佛波酯增强大鼠大脑皮层中血清素和乙酰胆碱释放的结构要求。
Br J Pharmacol. 1999 Jul;127(5):1177-89. doi: 10.1038/sj.bjp.0702627.
3
Enhancement by calcitonin gene-related peptide of nicotinic receptor-operated noncontractile Ca2+ mobilization at the mouse neuromuscular junction.降钙素基因相关肽增强小鼠神经肌肉接头处烟碱受体介导的非收缩性Ca2+动员
Br J Pharmacol. 1993 Oct;110(2):639-44. doi: 10.1111/j.1476-5381.1993.tb13859.x.
4
The upregulation of acetylcholine release at endplates of alpha-bungarotoxin-treated rats: its dependency on calcium.α-银环蛇毒素处理的大鼠终板处乙酰胆碱释放的上调：其对钙的依赖性。
J Physiol. 1994 Jul 1;478 ( Pt 1)(Pt 1):125-36. doi: 10.1113/jphysiol.1994.sp020236.
5
Activation of protein kinase C potentiates postsynaptic acetylcholine response at developing neuromuscular synapses.蛋白激酶C的激活增强了发育中的神经肌肉突触处的突触后乙酰胆碱反应。
Br J Pharmacol. 1993 Oct;110(2):707-12. doi: 10.1111/j.1476-5381.1993.tb13869.x.
6
Protein kinase C and presynaptic modulation of acetylcholine release in rabbit hippocampus.蛋白激酶C与兔海马体中乙酰胆碱释放的突触前调节
Br J Pharmacol. 1988 Mar;93(3):525-34. doi: 10.1111/j.1476-5381.1988.tb10307.x.
7
The influence of activation or inhibition of protein kinase C on the release of radioactivity from rat isolated atria labelled with [3H]-noradrenaline.蛋白激酶C的激活或抑制对用[3H]-去甲肾上腺素标记的大鼠离体心房放射性释放的影响。
Br J Pharmacol. 1988 Jul;94(3):713-20. doi: 10.1111/j.1476-5381.1988.tb11580.x.
8
Stimulation of spontaneous transmitter release at the frog neuromuscular junction by 12-O-tetradecanoylphorbol-13-acetate occurs in the absence of extracellular Ca2+ and is enhanced by depolarization.在无细胞外Ca2+的情况下，12-O-十四烷酰佛波醇-13-乙酸酯可刺激青蛙神经肌肉接头处的自发递质释放，且去极化可增强这种刺激作用。
Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):339-44. doi: 10.1007/BF00172107.
9
Influence of protein kinase C-stimulation by a phorbol ester on neurotransmitter release at frog end-plates.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):9-12. doi: 10.1007/BF00169469.
10
Regulation of acetylcholine receptor function by the phorbol ester TPA in rat skeletal muscle.
Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):82-6. doi: 10.1007/BF00169211.
本文引用的文献
1
Spontaneous subthreshold activity at motor nerve endings.运动神经末梢的自发性阈下活动。
J Physiol. 1952 May;117(1):109-28.
2
The effect of calcium and magnesium on the spontaneous release of transmitter from mammalian motor nerve endings.钙和镁对哺乳动物运动神经末梢递质自发释放的影响。
J Physiol. 1961 Dec;159(3):507-17. doi: 10.1113/jphysiol.1961.sp006824.
3
On the factors which determine the amplitude of the miniature end-plate potential.论决定微小终板电位幅度的因素。
J Physiol. 1957 Jul 11;137(2):267-78. doi: 10.1113/jphysiol.1957.sp005811.
4
Quantal components of the end-plate potential.终板电位的量子成分。
J Physiol. 1954 Jun 28;124(3):560-73. doi: 10.1113/jphysiol.1954.sp005129.
5
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.肿瘤促进剂佛波酯对钙激活的、磷脂依赖性蛋白激酶的直接激活作用。
J Biol Chem. 1982 Jul 10;257(13):7847-51.
6
Vesicle hypothesis of the release of quanta of acetylcholine.乙酰胆碱量子释放的囊泡假说。
Physiol Rev. 1980 Apr;60(2):396-441. doi: 10.1152/physrev.1980.60.2.396.
7
The phorbol ester TPA increases the affinity of exocytosis for calcium in 'leaky' adrenal medullary cells.佛波酯TPA增加了“渗漏”肾上腺髓质细胞中胞吐作用对钙的亲和力。
FEBS Lett. 1983 Aug 22;160(1-2):98-100. doi: 10.1016/0014-5793(83)80944-2.
8
Release of hydrolases and acetylcholine sensitivity in rat skeletal muscle.大鼠骨骼肌中水解酶的释放及乙酰胆碱敏感性
J Physiol. 1984 Jul;352:385-93. doi: 10.1113/jphysiol.1984.sp015298.
9
Pre-and post-junctional effects of tubocurarine and other nicotinic antagonists during repetitive stimulation in the rat.筒箭毒碱及其他烟碱样拮抗剂在大鼠重复刺激过程中的接头前和接头后效应
J Physiol. 1984 Jun;351:275-97. doi: 10.1113/jphysiol.1984.sp015245.
10
Inositol phospholipid hydrolysis in rat cerebral cortical slices: II. Calcium requirement.大鼠大脑皮层切片中的肌醇磷脂水解：II. 钙需求
J Neurochem. 1984 May;42(5):1388-94. doi: 10.1111/j.1471-4159.1984.tb02799.x.
Zotero 插件