Nutritional Epidemiology, DONALD Study, Department of Nutrition and Food Sciences, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.
Institute of General Practice and Family Medicine, Faculty of Medicine, Ruhr-University Bochum, Bochum, Germany.
Eur J Clin Nutr. 2022 May;76(5):765-771. doi: 10.1038/s41430-021-01024-y. Epub 2021 Oct 26.
BACKGROUND/OBJECTIVES: Adolescence is a critical period for both the development of overweight and the transition toward a later chronotype, often accompanied by an increase in social jetlag. This study assessed whether changes in chronotype and social jetlag, are linked to changes in body composition during adolescence.
SUBJECTS/METHODS: We used data from the DONALD open cohort study, collected between 2014 and 2019, from 213 adolescents (9-17 years at baseline, 45% females) having at least two measures of chronotype and anthropometry (N = 572). Chronotype was assessed with the Munich Chronotype Questionnaire and defined as: midpoint of sleep corrected for sleep-debt (MSFsc) accumulated over the week (later MSFsc represents later chronotype). Social jetlag (SJL) defines the difference between midpoint of sleep during week and weekend. Calculations for Fat Free Mass Index (FFMI [kg/m)]) and Fat Mass Index (FMI) [kg/m)]) were based on body fat percentage, weight, and height. To analyze the associations, we used linear mixed-effect regression models. Finally, the total cohort was split into three biologically relevant age groups (cut-off set at <12 years, ≥12 to ≤15 years and >15 years).
Median follow-up was 2.1 years. Overall, change toward a later chronotype was significantly related with an increase in FMI (ß: 0.05, 95% CI: 0.01-0.08). A 1 h increase in social jetlag predicted an increase in BMI-SDS of 0.08 SDS units (95% CI: 0.01-0.14) and in FMI of 0.04 kg/m2 (95% CI: 0.003-0.08). Associations were stronger for the age group ≥12 to ≤15 years (p for interaction: <0.001). No relationship was found with FFMI.
Changes in MSFsc and SJL during adolescence were associated with concurrent changes in BMI-SDS and FMI. The age ≥12 to ≤15 years appears to be a sensitive period in which chronobiological changes were clearly associated with increasing body fatness.
背景/目的：青春期是超重发展和向后期生物钟转变的关键时期，常伴随着社会时差的增加。本研究评估了青春期期间生物钟和社会时差的变化是否与身体成分的变化有关。
受试者/方法：我们使用了 DONALD 开放队列研究的数据，该研究于 2014 年至 2019 年期间收集，共涉及 213 名青少年（基线时年龄为 9-17 岁，女性占 45%），至少有两次生物钟和人体测量数据（N=572）。生物钟通过慕尼黑生物钟问卷进行评估，定义为：一周内累积的睡眠债务校正后的睡眠中点（MSFsc）（较晚的 MSFsc 代表较晚的生物钟）。社会时差（SJL）定义为周末期间的睡眠中点与周末期间的睡眠中点之间的差异。根据体脂百分比、体重和身高计算脂肪量指数（FFMI[kg/m）]）和脂肪质量指数（FMI[kg/m）]）。为了分析关联，我们使用了线性混合效应回归模型。最后，整个队列被分为三个生物学相关的年龄组（<12 岁、≥12 至≤15 岁和>15 岁）。
中位随访时间为 2.1 年。总体而言，向较晚生物钟的转变与 FMI 的增加显著相关（β：0.05，95%CI：0.01-0.08）。社会时差增加 1 小时可预测 BMI-SDS 增加 0.08 SDS 单位（95%CI：0.01-0.14）和 FMI 增加 0.04kg/m2（95%CI：0.003-0.08）。对于年龄组≥12 至≤15 岁的人群，关联更强（p 交互<0.001）。与 FFMI 无关系。
青春期 MSFsc 和 SJL 的变化与 BMI-SDS 和 FMI 的同时变化有关。12 至 15 岁年龄组似乎是一个敏感时期，在此期间，生物钟的变化与体脂增加明显相关。
Zotero 插件