Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Acta Med Okayama. 2021;75(5):625-629. doi: 10.18926/AMO/62775.
A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases.
一位 77 岁的日本女性，曾患有滤泡性淋巴瘤 8 年，出现腹痛和腹腔内淋巴结病。结肠镜检查显示直肠有一处隆起性病变，呈两个带有侵蚀的驼峰状。经内镜活检诊断为滤泡性淋巴瘤向弥漫性大 B 细胞淋巴瘤的组织学转化。本例强调了内镜检查和新出现的胃肠道病变活检对于及时诊断组织学转化的重要性，因为在这种情况下必须迅速启动挽救性化疗。
