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乳酸酸中毒作为未分化癌的一种罕见表现

Lactic Acidosis as an Unusual Finding in Undifferentiated Carcinoma.

作者信息

Viteri-Noel Adrian, Cobo-Reinoso Maria Eugenia, de Felipe-Noguerales Blanca, Manzano Luis

机构信息

Internal Medicine Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

Haematology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

出版信息

Case Rep Oncol. 2021 Aug 16;14(2):1237-1241. doi: 10.1159/000517853. eCollection 2021 May-Aug.

Abstract

Lactic acidosis associated with solid neoplasms is a rare complication; its occurrence is poorly described, and it is associated with a poor prognosis. We present the case of an 84-year-old woman who was admitted to the internal medicine department with a diagnosis of urinary tract infection accompanied by a blood gas analysis showing lactic acidosis. During her admission, an abdominal mass was evidenced and finally diagnosed as undifferentiated carcinoma. We wanted to emphasize the importance of correlating clinical and laboratory data at the time of making a diagnostic approach and also highlight other possible explanations of lactic acidosis that should be considered in addition to hypoperfusion due to sepsis, especially in the elderly who are at increased risk of malignancy.

摘要

与实体肿瘤相关的乳酸性酸中毒是一种罕见的并发症;其发生情况描述甚少,且与预后不良相关。我们报告一例84岁女性患者,因诊断为尿路感染入住内科,血气分析显示存在乳酸性酸中毒。住院期间发现腹部有肿物,最终诊断为未分化癌。我们想强调在进行诊断时关联临床和实验室数据的重要性,同时突出除败血症导致的灌注不足外,乳酸性酸中毒的其他可能原因也应予以考虑,尤其是在恶性肿瘤风险增加的老年患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da58/8460945/e37c72ba8eb7/cro-0014-1237-g01.jpg

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