B型乳酸酸中毒：一种罕见的肿瘤急症。
Type B lactic acidosis: a rare oncological emergency.
作者信息
Liu Qiuying Selina, Harji Farzana, Jones Anna, Tarnower Amy C
机构信息
Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
出版信息
BMJ Case Rep. 2020 Mar 31;13(3):e233068. doi: 10.1136/bcr-2019-233068.
Abstract
Type B lactic acidosis is a rare metabolic complication of malignancy, more commonly in haematological malignancies. Due to the lack of formal prospective trials, treatment of lactic acidosis associated with malignancy is based on case reports. Given the poor prognosis, early recognition of type B lactic acidosis and prompt treatment are crucial. We report the first case of type B lactic acidosis in metastatic melanoma, followed by a brief literature review on the proposed pathophysiology and treatment.
摘要
B型乳酸酸中毒是恶性肿瘤罕见的代谢并发症，更常见于血液系统恶性肿瘤。由于缺乏正规的前瞻性试验，与恶性肿瘤相关的乳酸酸中毒的治疗基于病例报告。鉴于预后较差，早期识别B型乳酸酸中毒并及时治疗至关重要。我们报告了转移性黑色素瘤中首例B型乳酸酸中毒病例，随后对提出的病理生理学和治疗方法进行简要文献综述。
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本文引用的文献
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2
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Cancer Metastasis Rev. 2019 Jun;38(1-2):149-155. doi: 10.1007/s10555-019-09787-4.
3
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