Iranmanesh Farhad, Syfadini Rostam, Mahalati Yaseman, Gadari Faranak, Dehesh Tania
Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Department of Biostatistics and Epidemiology, School of Health, Kerman University of Medical Sciences, Kerman, Iran.
Addict Health. 2021 Apr;13(2):114-119. doi: 10.22122/ahj.v13i2.302.
There is no consensus on the effect of opium on stroke yet. Some studies show the negative effects of opium on ischemic strokes. Here, we attempt to compare the volume of lesions in opium addict and non-addict patients with thrombotic stroke.
This case-control study was conducted on patients with thrombotic stroke at Shafa Hospital in Kerman, Iran. The diagnosis was confirmed by clinical examinations, imaging, and laboratory tests. The volume of lesions was calculated by magnetic resonance imaging (MRI), and the data were analyzed by descriptive statistics, Mann-Whitney U test, Chi-square test, and linear regression analysis.
A total of 60 patients were studied, 30 of whom were opium addicts and the rest were non-addicts. The mean volume of the lesion was 46.008350 ± 7.488990 (in the addict group) and 31.023335 ± 1.441570 (in the non-addict group), indicating a significant difference between the two groups (P = 0.005). Regression analysis results showed a significant relationship between the volume of stroke with opium addiction (P = 0.017), ischemic heart diseases (IHDs) (P = 0.006), hyperlipidemia (HLP) (P = 0.016), age (P = 0.035), and smoking (P = 0.044).
The results of this study showed a higher volume of lesion in opium-addict patients compared to that in non-addicts as an indicator of stroke severity.
关于鸦片对中风的影响尚无定论。一些研究显示鸦片对缺血性中风有负面影响。在此，我们试图比较鸦片成瘾者和非成瘾者血栓性中风患者的病灶体积。
本病例对照研究在伊朗克尔曼省沙法医院的血栓性中风患者中进行。通过临床检查、影像学检查和实验室检查确诊。通过磁共振成像（MRI）计算病灶体积，并采用描述性统计、曼-惠特尼U检验、卡方检验和线性回归分析对数据进行分析。
共研究了60例患者，其中30例为鸦片成瘾者，其余为非成瘾者。成瘾组病灶平均体积为46.008350±7.488990，非成瘾组为31.023335±1.441570，两组间差异有统计学意义（P = 0.005）。回归分析结果显示中风体积与鸦片成瘾（P = 0.017）、缺血性心脏病（IHDs）（P = 0.006）、高脂血症（HLP）（P = 0.016）、年龄（P = 0.035）和吸烟（P = 0.044）之间存在显著相关性。
本研究结果显示，作为中风严重程度的一个指标，鸦片成瘾患者的病灶体积比非成瘾患者更大。
