Sharova Oleksandra, Smiyan Oleksandr, Borén Thomas
Department of Pediatrics, Sumy State University, 40031, Sumy, Ukraine.
Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187, Umeå, Sweden.
Brain Behav Immun Health. 2021 Oct 9;18:100365. doi: 10.1016/j.bbih.2021.100365. eCollection 2021 Dec.
Cerebral palsy (CP) is a group of motor disorders caused by non-progressive lesions of the premature brain with lifelong pathophysiological consequences that include dysregulation of innate immunity. Persistent inflammation with increased levels of circulating pro-inflammatory tumor necrosis factor alpha (TNF-a) is negatively associated with rehabilitation outcome in children with CP. Because of the crosstalk between innate and adaptive immunity, we investigated the effect of CP and rehabilitation exercises on the adaptive immune system in children with CP by measuring the levels of CD3, CD4, CD8 Т-cells, and CD22 B-cells and the levels of immunoglobulins. Children with CP had higher levels of CD3, CD4, CD8 Т-cells, and CD22 B-cells compared to healthy children, and the rehabilitation exercise programs produced better outcomes in terms of increased gains in motor function at an earlier age. Rehabilitation exercises performed over a month resulted in significantly decreased levels of IgA in serum and reduced numbers of B-lymphocytes and reduced IgM levels. Our study suggests that rehabilitation programs with a focus on neuroplasticity and physical exercises in children with CP can reduce both cellular and humoral immune responses.
脑性瘫痪（CP）是一组由早产脑的非进行性病变引起的运动障碍，具有终身病理生理后果，包括先天免疫失调。循环中促炎性肿瘤坏死因子α（TNF-α）水平升高导致的持续性炎症与CP患儿的康复结果呈负相关。由于先天免疫和适应性免疫之间存在相互作用，我们通过测量CD3、CD4、CD8 T细胞、CD22 B细胞水平以及免疫球蛋白水平，研究了CP和康复锻炼对CP患儿适应性免疫系统的影响。与健康儿童相比，CP患儿的CD3、CD4、CD8 T细胞和CD22 B细胞水平更高，康复锻炼计划在更早年龄提高运动功能方面产生了更好的效果。持续一个月的康复锻炼导致血清中IgA水平显著降低、B淋巴细胞数量减少以及IgM水平降低。我们的研究表明，以CP患儿的神经可塑性和体育锻炼为重点的康复计划可以降低细胞免疫和体液免疫反应。
