与 Dupuytren 病治疗的发展、进展和结局相关的因素：系统评价。

Factors Associated with the Development, Progression, and Outcome of Dupuytren Disease Treatment: A Systematic Review.

机构信息

From the Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London; Nuffield Departments of Orthopaedics, Rheumatology, and Musculoskeletal Science and Population Health, University of Oxford; Imperial College School of Medicine; School of Health Sciences, University of East Anglia; Department of Symptom Research, Division of Internal Medicine, University of Texas M. D. Anderson Cancer Center; and Department of Plastic Surgery, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust.

出版信息

Plast Reconstr Surg. 2021 Nov 1;148(5):753e-763e. doi: 10.1097/PRS.0000000000008420.

DOI:10.1097/PRS.0000000000008420

PMID:34705778

Abstract

BACKGROUND

The factors typically considered to be associated with Dupuytren disease have been described, such as those in the "Dupuytren diathesis." However, the quality of studies describing them has not been appraised. This systematic review aimed to analyze the evidence for all factors investigated for potential association with the development, progression, outcome of treatment, or recurrence of Dupuytren disease.

METHODS

A systematic review of the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and Cumulative Index to Nursing and Allied Health Literature databases was conducted using a Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant methodology up to September of 2019. Articles were screened in duplicate. Prognostic studies were quality assessed using the Quality in Prognosis Study tool.

RESULTS

This study identified 2301 records; 51 met full inclusion criteria reporting data related to 54,491 patients with Dupuytren disease. In total, 46 candidate factors associated with the development of Dupuytren disease were identified. There was inconsistent evidence between the association of Dupuytren disease and the presence of "classic" diathesis factors. The quality of included studies varied, and the generalizability of studies was low. There was little evidence describing the factors associated with functional outcome.

CONCLUSIONS

This systematic review challenges conventional notions of diathesis factors. Traditional diathesis factors are associated with disease development and recurrence, although they are not significantly associated with poor outcome following intervention based on the current evidence.

摘要

背景

已描述了通常被认为与掌腱膜挛缩症相关的因素，例如“掌腱膜挛缩症体质”。然而，描述这些因素的研究质量尚未得到评估。本系统评价旨在分析所有潜在与掌腱膜挛缩症的发展、进展、治疗结果或复发相关的因素的证据。

方法

使用符合系统评价和荟萃分析报告的首选项目（Preferred Reporting Items for Systematic Reviews and Meta-Analyses，PRISMA）方法，对 Cochrane 中央对照试验注册库、MEDLINE、Embase 和 Cumulative Index to Nursing and Allied Health Literature 数据库进行了系统评价，检索截至 2019 年 9 月。文章采用双盲筛选。使用预后研究质量评估工具（Quality in Prognosis Study tool）对预后研究进行质量评估。

结果

本研究共确定了 2301 条记录，其中 51 条符合全部纳入标准，共纳入了 54491 例掌腱膜挛缩症患者的数据。总共确定了 46 个与掌腱膜挛缩症发生相关的候选因素。掌腱膜挛缩症与“经典”体质因素之间的关联存在不一致的证据。纳入研究的质量参差不齐，研究的普遍性较低。几乎没有证据描述与功能结果相关的因素。