嵌套：变构相互作用的层次结构。
Nesting: hierarchies of allosteric interactions.
作者信息
Robert C H, Decker H, Richey B, Gill S J, Wyman J
出版信息
Proc Natl Acad Sci U S A. 1987 Apr;84(7):1891-5. doi: 10.1073/pnas.84.7.1891.
Abstract
A generalization of the allosteric model is presented that incorporates a hierarchy of conformational equilibria. Such a formulation draws upon structural organization already seen in many large macromolecular systems. The functional binding properties of the macromolecule reflect conformational equilibria at each structural level. Appropriate "nested" models are used to interpret structural features and functional aspects of two hemocyanin systems with a large number (12 and 24) of binding sites.
摘要
提出了一种变构模型的推广形式，该模型纳入了构象平衡的层次结构。这种表述借鉴了许多大型大分子系统中已有的结构组织。大分子的功能结合特性反映了每个结构层次上的构象平衡。使用适当的“嵌套”模型来解释具有大量（12个和24个）结合位点的两个血蓝蛋白系统的结构特征和功能方面。
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