Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Key Lab of Holistic Integrative Enterology, Nanjing Medical University, Nanjing, China.
Front Public Health. 2021 Oct 11;9:731578. doi: 10.3389/fpubh.2021.731578. eCollection 2021.
To explore the attitudes and views of patients with inflammatory bowel disease (IBD) on COVID-19 vaccination. An online interview questionnaire concerning the acceptance or hesitancy toward vaccination for COVID-19 was designed and 543 patients with IBD in China were invited to complete the structured self-administered anonymous questionnaire. Of all the participants, 50.7% were indecisive about the vaccination and only 16.0% opted for it. Vaccination hesitancy was significantly associated with women and those without medical or biomedical backgrounds. The acceptance of COVID-19 vaccination was higher in participants with no history of immune-modifying therapies, especially in those without immunosuppressants. Participants who considered vaccination critically important to self-health or the health of others were more likely to choose immediately or later vaccination. Safety and potential adverse reactions, personal hypoimmunity, efficacy, and reliability of COVID-19 vaccines were the top three concerns of the participants that were independent of their willingness for vaccination. This study discloses the presence of hesitancy for COVID-19 vaccination in patients with IBD. Further studies are warranted to evaluate the efficacy and safety of COVID-19 vaccines in IBD individuals, with a specific focus on the impact of immune-modifying therapies. Health education and recommendation from authoritative sources may facilitate COVID-19 vaccination efforts.
探讨炎症性肠病（IBD）患者对 COVID-19 疫苗接种的态度和看法。方法：设计了一份关于 COVID-19 疫苗接种接受或犹豫的在线访谈问卷，邀请了 543 名中国 IBD 患者完成了结构化的自我管理匿名问卷。结果：所有参与者中，50.7%对疫苗接种犹豫不决，只有 16.0%选择接种。疫苗犹豫与女性和无医学或生物医学背景的人显著相关。在没有免疫调节治疗史的参与者中，对 COVID-19 疫苗接种的接受程度更高，尤其是在没有免疫抑制剂的参与者中。那些认为接种对自身或他人健康至关重要的参与者更有可能选择立即或以后接种。疫苗的安全性和潜在不良反应、个人低免疫性、有效性和可靠性是参与者最关注的前三个问题，与他们的接种意愿无关。结论：本研究揭示了 IBD 患者对 COVID-19 疫苗接种的犹豫。需要进一步研究评估 COVID-19 疫苗在 IBD 个体中的疗效和安全性，特别关注免疫调节治疗的影响。健康教育和权威来源的建议可能有助于 COVID-19 疫苗接种工作。
