Department of Obstetrics and Gynaecology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
Department of Obstetrics and Gynaecology, Usmanu Danfodiyo University/Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
Niger Postgrad Med J. 2021 Jul-Sep;28(3):187-192. doi: 10.4103/npmj.npmj_404_21.
The most common major obstetric procedure is caesarean section (CS) and one of the greatest concerns for women after CS is to have optimal pain relief.
This study aims to compare the efficacy of pentazocine + diclofenac and paracetamol + diclofenac on post-operative analgesia after CS.
This was a single-blind, randomised trial. Pregnant women that had CS were randomized into two groups. Group A received intramuscular pentazocine + rectal diclofenac postoperatively. Group B received intramuscular paracetamol + rectal diclofenac postoperatively. Post-operative pain was assessed by numeric rating scale at 1 h after the surgery, at 6 h, 12 h and 24 h. The result obtained was analysed using SPSS Version 22 and P < 0.05 was considered statistically significant.
The median pain scores in both groups ranged from 2 to 3 across all periods of assessment. The pain relief was slightly better in the pentazocine + diclofenac group with no significant difference in the pain score between the two groups at all periods of assessment. The satisfaction level was good in 66.3% and 69.5% of the participants in the pentazocine + diclofenac and paracetamol + diclofenac group respectively but the difference was not statistically significant (χ = 4.14, P = 0. 12). Nausea, vomiting and drowsiness were significantly more in the pentazocine + diclofenac combination (P < 0.001).
Both combination of analgesics provided adequate analgesia but pentazocine + diclofenac combination had better pain relief but was more associated with side effects.
最常见的主要产科手术是剖宫产（CS），而 CS 后女性最关心的问题之一是获得最佳的止痛效果。
本研究旨在比较戊酸哌替啶+双氯芬酸和对乙酰氨基酚+双氯芬酸在 CS 后术后镇痛中的疗效。
这是一项单盲、随机试验。接受 CS 的孕妇被随机分为两组。A 组术后接受肌肉注射戊酸哌替啶+直肠双氯芬酸。B 组术后接受肌肉注射对乙酰氨基酚+直肠双氯芬酸。术后疼痛采用数字评分量表在手术后 1 小时、6 小时、12 小时和 24 小时进行评估。使用 SPSS 版本 22 分析获得的结果，P<0.05 被认为具有统计学意义。
两组的中位数疼痛评分在所有评估期间均为 2 至 3 分。戊酸哌替啶+双氯芬酸组的止痛效果稍好，但两组在所有评估期间的疼痛评分均无显著差异。戊酸哌替啶+双氯芬酸组和对乙酰氨基酚+双氯芬酸组的满意度分别为 66.3%和 69.5%，但差异无统计学意义（χ=4.14，P=0.12）。戊酸哌替啶+双氯芬酸组恶心、呕吐和嗜睡的发生率明显更高（P<0.001）。
两种镇痛药组合均能提供充分的镇痛效果，但戊酸哌替啶+双氯芬酸组合的止痛效果更好，但副作用更多。
