Luomanen M
Scand J Dent Res. 1987 Feb;95(1):65-73. doi: 10.1111/j.1600-0722.1987.tb01395.x.
Capillary proliferation and inflammatory cell infiltration were evaluated in healing laser and scalpel incision wounds in rat tongue mucosa in 22 Sprague-Dawley rats for a period of 28 days. The incisions were made in parallel on both sides of the midline of the tongue. Specimens for immunohistochemical and histologic examination were taken immediately, 6 h, 2, 11, and 28 days after the surgery. The microscopic inspection of the sections stained immunohistologically for factor VIII-related antigen, a marker for endothelial cells, suggested a smaller amount of capillaries immediately and during the early healing phase in the vicinity of the laser incisions when compared with the scalpel incisions. The proliferation of capillaries during healing was also retarded at the lasered sites. The microscopic inspection of the histologic specimens showed that the inflammatory cell infiltration appeared slower but was more prominent in the healing laser wounds than in the healing scalpel incision wounds.
在22只Sprague-Dawley大鼠的舌黏膜上制作愈合的激光和手术刀切口伤口，评估毛细血管增殖和炎性细胞浸润情况，为期28天。在舌中线两侧平行制作切口。在手术后立即、6小时、2天、11天和28天采集用于免疫组织化学和组织学检查的标本。对切片进行免疫组织化学染色，以检测内皮细胞标志物VIII因子相关抗原，显微镜检查表明，与手术刀切口相比，激光切口附近在愈合即刻和早期愈合阶段的毛细血管数量较少。激光照射部位愈合过程中毛细血管的增殖也受到抑制。组织学标本的显微镜检查显示，炎性细胞浸润在激光伤口愈合过程中出现较慢，但比手术刀切口愈合伤口更为明显。
