十二指肠内给予¹³¹I标记的人阳离子胰蛋白酶后血浆中放射性的特征分析。

Characterization of radioactivity in plasma after intraduodenal administration of 131I-labelled human cationic trypsin.

作者信息

Bohe M, Borgström A, Genell S, Ohlsson K

出版信息

Scand J Gastroenterol Suppl. 1986;126:21-4. doi: 10.3109/00365528609091887.

Abstract

Active human pancreatic cationic trypsin labelled with 131I was administered into the duodenum in nine healthy individuals pretreated with "cold", i.e. non-radioactive iodine. Radioactivity in plasma was measured during 72 hours and was present in plasma after 15 minutes with a maximum 1 hour after administration. The recovered radioactivity in plasma was characterized using dialysis and gel-filtration and the radioactive iodine was found to be in the form of free 131I. Our results are in agreement with recent experimental studies indicating the presence of de-iodinases in the intestine. Furthermore, it was found that pretreatment with "cold" iodine prevented isotope binding to circulating plasma proteins.

摘要

将用¹³¹I标记的活性人胰阳离子胰蛋白酶注入9名用“冷”（即非放射性碘）预处理的健康个体的十二指肠。在72小时内测量血浆中的放射性，给药后15分钟血浆中就有放射性，给药后1小时达到最大值。用透析和凝胶过滤对血浆中回收的放射性进行表征，发现放射性碘呈游离¹³¹I的形式。我们的结果与最近表明肠道中存在脱碘酶的实验研究一致。此外，还发现用“冷”碘预处理可防止同位素与循环血浆蛋白结合。