《巴西家族性高胆固醇血症指南（2021年版）》更新 - Suppr

Update of the Brazilian Guideline for Familial Hypercholesterolemia - 2021.

作者信息

Izar Maria Cristina de Oliveira, Giraldez Viviane Zorzanelli Rocha, Bertolami Adriana, Santos Filho Raul Dias Dos, Lottenberg Ana Maria, Assad Marcelo Heitor Vieira, Saraiva José Francisco Kerr, Chacra Ana Paula M, Martinez Tania L R, Bahia Luciana Ribeiro, Fonseca Francisco Antonio Helfenstein, Faludi Andre Arpad, Sposito Andrei C, Chagas Antônio Carlos Palandri, Jannes Cinthia Elim, Amaral Cristiane Kovacs, Araújo Daniel Branco de, Cintra Dennys Esper, Coutinho Elaine Dos Reis, Cesena Fernando, Xavier Hermes Toros, Mota Isabela Cardoso Pimentel, Giuliano Isabela de Carlos Back, Faria Neto José Rocha, Kato Juliana Tieko, Bertolami Marcelo Chiara, Miname Marcio Hiroshi, Castelo Maria Helane Costa Gurgel, Lavrador Maria Sílvia Ferrari, Machado Roberta Marcondes, Souza Patrícia Guedes de, Alves Renato Jorge, Machado Valeria Arruda, Salgado Filho Wilson

机构信息

Universidade Federal de São Paulo (UNIFESP), São Paulo, SP - Brasil.

Instituto do Coração (InCor) da Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP - Brasil.

出版信息

Arq Bras Cardiol. 2021 Oct;117(4):782-844. doi: 10.36660/abc.20210788.

DOI:10.36660/abc.20210788

PMID:34709306

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8528358/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17df/8528358/93c7bca45e80/0066-782X-abc-117-04-0782-gf01.jpg

相似文献

Update of the Brazilian Guideline for Familial Hypercholesterolemia - 2021.《巴西家族性高胆固醇血症指南（2021年版）》更新

Arq Bras Cardiol. 2021 Oct;117(4):782-844. doi: 10.36660/abc.20210788.

[First Brazilian Guidelines for Familial Hypercholesterolemia].[巴西首部家族性高胆固醇血症指南]

Arq Bras Cardiol. 2012 Aug;99(2 Suppl 2):1-28. doi: 10.5935/abc.20120202.

Diagnosis and Treatment of Heterozygous Familial Hypercholesterolemia.杂合子家族性高胆固醇血症的诊断与治疗

J Am Heart Assoc. 2019 Dec 17;8(24):e013225. doi: 10.1161/JAHA.119.013225. Epub 2019 Dec 16.

Identification and Management of Heterozygous Familial Hypercholesterolemia. Proceedings of a workshop. July 20-21, 1992.杂合子家族性高胆固醇血症的识别与管理。研讨会论文集。1992年7月20 - 21日

Am J Cardiol. 1993 Sep 30;72(10):1D-84D.

Management of patients with homozygous familial hypercholesterolemia.纯合子家族性高胆固醇血症患者的管理

Am J Manag Care. 2013 Nov;19(13 Suppl):s.

Coronary Artery Calcification in Familial Hypercholesterolemia: An Opportunity for Risk Assessment and Shared Decision Making With the Power of Zero?家族性高胆固醇血症中的冠状动脉钙化：借助“零风险”理念进行风险评估和共同决策的契机？

Circulation. 2020 Oct 13;142(15):1405-1407. doi: 10.1161/CIRCULATIONAHA.120.049057. Epub 2020 Oct 12.

The Agenda for Familial Hypercholesterolemia: A Scientific Statement From the American Heart Association.家族性高胆固醇血症议程：美国心脏协会的科学声明

Circulation. 2015 Dec 1;132(22):2167-92. doi: 10.1161/CIR.0000000000000297. Epub 2015 Oct 28.

Familial hypercholesterolemia: clues to catching it early.家族性高胆固醇血症：早期发现的线索

J Fam Pract. 2015 Aug;64(8):464-9.

Familial hypercholesterolemia: a challenge of diagnosis and therapy.家族性高胆固醇血症：诊断与治疗的挑战。

Cleve Clin J Med. 2006 Jan;73(1):57-64. doi: 10.3949/ccjm.73.1.57.

Familial hypercholesterolemia. There is a need for early detection and treatment.家族性高胆固醇血症。需要早期检测和治疗。

JAMA. 1987 Jan 2;257(1):69-70. doi: 10.1001/jama.257.1.69.

引用本文的文献

Single-base polymorphism of the ACE2 and TNF-alpha genes in patients with the cardiac and indeterminate forms of Chagas disease.恰加斯病心脏型和不确定型患者中ACE2和TNF-α基因的单碱基多态性

Braz J Infect Dis. 2025 Sep-Oct;29(5):104574. doi: 10.1016/j.bjid.2025.104574. Epub 2025 Aug 14.

An Adapted Cardioprotective Diet with or Without Phytosterol and/or Krill Oil Supplementation in Familial Hypercholesterolemia: Results of a Pilot Randomized Clinical Trial.家族性高胆固醇血症患者采用添加或不添加植物甾醇和/或磷虾油的改良心脏保护饮食：一项试点随机临床试验的结果

Nutrients. 2025 Jun 15;17(12):2008. doi: 10.3390/nu17122008.

Detecting Familial Hypercholesterolemia in Adolescents: Universal Screening is Key.检测青少年家族性高胆固醇血症：普遍筛查是关键。

Arq Bras Cardiol. 2025 May 23;122(3):e20250178. doi: 10.36660/abc.20250178. eCollection 2025.

Cascade Screening in Adolescents with Lipid Disorders Suggestive of Familial Hypercholesterolemia: Findings from the ERICA Study in Curitiba.对疑似家族性高胆固醇血症的青少年血脂异常进行级联筛查：库里蒂巴ERICA研究的结果

Arq Bras Cardiol. 2025 Mar;122(3):e20240468. doi: 10.36660/abc.20240468.

New cardiovascular disease markers in patients with familial hypercholesterolemia carriers of genetic variants.家族性高胆固醇血症基因变异携带者患者的新型心血管疾病标志物。

J Diabetes Metab Disord. 2024 Dec 16;24(1):13. doi: 10.1007/s40200-024-01537-w. eCollection 2025 Jun.

Cardiovascular Computed Tomography and Magnetic Resonance Imaging Guideline of the Brazilian Society of Cardiology and the Brazilian College of Radiology - 2024.巴西心脏病学会和巴西放射学会心血管计算机断层扫描与磁共振成像指南 - 2024年

Arq Bras Cardiol. 2024 Oct 28;121(9):e20240608. doi: 10.36660/abc.20240608.

Gene Mutation in Patients with Familial Hypercholesterolemia and Response to Alirocumab Treatment-A Single-Centre Analysis.家族性高胆固醇血症患者的基因突变及对阿利西尤单抗治疗的反应——一项单中心分析

J Clin Med. 2024 Sep 22;13(18):5615. doi: 10.3390/jcm13185615.

Methylation status of , and is associated with cardiovascular events in familial hypercholesterolemia.、和的甲基化状态与家族性高胆固醇血症中的心血管事件相关。

Epigenomics. 2024;16(11-12):809-820. doi: 10.1080/17501911.2024.2351792. Epub 2024 Jun 17.

Prevalence and factors associated with possible cases of familial hypercholesterolemia in Brazilian adults: a cross-sectional study.巴西成年人家族性高胆固醇血症疑似病例的流行情况及相关因素：一项横断面研究。

Sci Rep. 2023 Nov 22;13(1):20459. doi: 10.1038/s41598-023-47692-7.

Pathophysiology and Treatment of Lipid Abnormalities in Cerebrotendinous Xanthomatosis: An Integrative Review.脑腱黄瘤病脂质异常的病理生理学与治疗：一项综合综述

Brain Sci. 2023 Jun 22;13(7):979. doi: 10.3390/brainsci13070979.

本文引用的文献

Clinical implications and outcomes of the ORION Phase III trials.ORION三期试验的临床意义及结果

Future Cardiol. 2021 Aug;17(5):769-777. doi: 10.2217/fca-2020-0150. Epub 2020 Dec 21.

Evinacumab in Patients with Refractory Hypercholesterolemia.依洛尤单抗治疗难治性高胆固醇血症患者的疗效。

N Engl J Med. 2020 Dec 10;383(24):2307-2319. doi: 10.1056/NEJMoa2031049. Epub 2020 Nov 15.

Long-term safety and efficacy of lomitapide in patients with homozygous familial hypercholesterolemia: Five-year data from the Lomitapide Observational Worldwide Evaluation Registry (LOWER).载脂蛋白 B 代谢类药物 lomitapide 治疗纯合子家族性高胆固醇血症患者的长期安全性和疗效：来自 lomitapide 观察性全球评估注册研究（LOWER）的 5 年数据。

J Clin Lipidol. 2020 Nov-Dec;14(6):807-817. doi: 10.1016/j.jacl.2020.08.006. Epub 2020 Aug 19.

Evolocumab in Pediatric Heterozygous Familial Hypercholesterolemia.依洛尤单抗在儿科杂合子家族性高胆固醇血症中的应用。

N Engl J Med. 2020 Oct 1;383(14):1317-1327. doi: 10.1056/NEJMoa2019910. Epub 2020 Aug 29.

Evinacumab for Homozygous Familial Hypercholesterolemia.依洛尤单抗治疗纯合子家族性高胆固醇血症。

N Engl J Med. 2020 Aug 20;383(8):711-720. doi: 10.1056/NEJMoa2004215.

Prevalence of Familial Hypercholesterolemia Among the General Population and Patients With Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-Analysis.家族性高胆固醇血症在普通人群和动脉粥样硬化性心血管疾病患者中的患病率：系统评价和荟萃分析。

Circulation. 2020 Jun 2;141(22):1742-1759. doi: 10.1161/CIRCULATIONAHA.119.044795. Epub 2020 May 29.

Worldwide Prevalence of Familial Hypercholesterolemia: Meta-Analyses of 11 Million Subjects.全球家族性高胆固醇血症患病率的Meta 分析：1100 万例患者研究

J Am Coll Cardiol. 2020 May 26;75(20):2553-2566. doi: 10.1016/j.jacc.2020.03.057.

PCSK9 inhibition with alirocumab in pediatric patients with heterozygous familial hypercholesterolemia: The ODYSSEY KIDS study.阿利西尤单抗对杂合子家族性高胆固醇血症儿科患者PCSK9的抑制作用：ODYSSEY KIDS研究

J Clin Lipidol. 2020 May-Jun;14(3):322-330.e5. doi: 10.1016/j.jacl.2020.03.001. Epub 2020 Mar 28.

Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia.英克西兰用于治疗杂合子家族性高胆固醇血症。

N Engl J Med. 2020 Apr 16;382(16):1520-1530. doi: 10.1056/NEJMoa1913805. Epub 2020 Mar 18.

Long-Term Evolocumab in Patients With Familial Hypercholesterolemia.长期依洛尤单抗治疗家族性高胆固醇血症患者的疗效。

J Am Coll Cardiol. 2020 Feb 18;75(6):565-574. doi: 10.1016/j.jacc.2019.12.020.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Update of the Brazilian Guideline for Familial Hypercholesterolemia - 2021.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献检索

文件翻译

深度研究

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献