Postgraduate Nursing Program, Nursing School, Federal University of Minas Gerais (UFMG), Avenue Alfredo Balena, No 190, Santa Efigênia, Belo Horizonte, MG, CEP 30130-100, Brazil.
Postgraduate Program in Public Health, Faculty of Medicine of the Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Sci Rep. 2023 Nov 22;13(1):20459. doi: 10.1038/s41598-023-47692-7.
This study aimed to estimate the prevalence of possible cases of FH and analyze associated factors in the adult Brazilian population. Cross-sectional study with laboratory data from the Brazilian National Health Survey, with 8521 participants. Possible cases of FH were defined according to the Dutch Lipid Clinic Network criteria. The prevalence and 95% confidence intervals (95% CI) of possible cases of FH were estimated according to sociodemographic variables, lifestyle, diabetes, hypertension, altered tests, treatment and self-rated health. Logistic regression was used to analyze the associations. The prevalence of possible cases of FH was 0.96%, higher in women, between 45 and 59 years, white race/skin color and others, less education, people with diabetes, hypertension and total cholesterol ≥ 310 mg/dL. The presence of FH was positively associated with regular self-rated health (OR 1.96; 95% CI 0.99-3.84), poor/very poor (OR 3.02; 95% CI 1.30-7.03) and negatively with black race/skin color (OR 0.10; 95% CI 0.02-0.46) and complete elementary school, incomplete high school (OR 0.47; 95% CI 0.23-0.98) and complete high school and more (OR 0.45; 95% CI 0.21-0.95). FH affects 1:104 Brazilian adults, these findings contribute to understanding the burden of disease in Brazil. Due to the scarcity of studies on FH in low- and middle-income countries, further studies are desirable.
本研究旨在估计巴西成年人中可能的 FH 病例的患病率，并分析相关因素。这是一项横断面研究，使用了巴西国家健康调查的实验室数据，共纳入了 8521 名参与者。根据荷兰血脂临床网络标准，将 FH 的可能病例定义为符合条件的患者。根据社会人口统计学变量、生活方式、糖尿病、高血压、改变的测试、治疗和自我评估的健康状况，估计了 FH 可能病例的患病率及其 95%置信区间（95%CI）。使用逻辑回归分析了关联。FH 可能病例的患病率为 0.96%，女性、45-59 岁、白种人/肤色和其他人、受教育程度较低、患有糖尿病、高血压和总胆固醇≥310mg/dL 的人群中患病率更高。FH 的存在与定期自我评估的健康状况呈正相关（OR 1.96；95%CI 0.99-3.84），与较差/非常差呈正相关（OR 3.02；95%CI 1.30-7.03），与黑种人/肤色呈负相关（OR 0.10；95%CI 0.02-0.46），与完全小学、不完全高中（OR 0.47；95%CI 0.23-0.98）和完全高中及以上（OR 0.45；95%CI 0.21-0.95）呈负相关。FH 影响每 104 名巴西成年人中的 1 人，这些发现有助于了解巴西的疾病负担。由于在中低收入国家中 FH 的研究较少，因此还需要进一步的研究。
