通过组织学和免疫组织化学方法评估登革病毒在小鼠和人类中的发病机制。
Evaluating Dengue Virus Pathogenesis in Mice and Humans by Histological and Immunohistochemistry Approaches.
作者信息
Salomão Natália G, Rabelo Kíssila, Paes Marciano V
机构信息
Interdisciplinary Laboratory of Medical Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Laboratory of Ultrastructure and Tissue Biology, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
出版信息
Methods Mol Biol. 2022;2409:259-269. doi: 10.1007/978-1-0716-1879-0_18.
The analysis of dengue virus (DENV) infected tissues in mice experimental model and in human biopsies/autopsies may support the pathogenesis studies. Through such models, it is possible to investigate possible histopathological changes caused by the infection and detections of different targets of interest, such as viral antigens, immune cells, and cytokines. In this chapter, we showed a brief review of how histological and immunohistochemistry approaches may improve the knowledge in this field.
对小鼠实验模型以及人类活检/尸检中的登革病毒（DENV）感染组织进行分析，可能会为发病机制研究提供支持。通过此类模型，有可能研究感染引起的可能的组织病理学变化，并检测不同的目标物，如病毒抗原、免疫细胞和细胞因子。在本章中，我们简要回顾了组织学和免疫组织化学方法如何增进该领域的知识。
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