Seth Nimish, Seth Ishith, Bulloch Gabriella, Siu Adrian Hang Yue, Guo Allen, Chatterjee Rukmini, MacManus Michael, Donnan Leo
Department of Orthopaedic Surgery, The Alfred Hospital, Melbourne, Victoria, Australia.
Illawarra Shoalhaven Local Health District, Wollongong Hospital, Wollongong, New South Wales, Australia.
Pediatr Blood Cancer. 2022 Mar;69(3):e29415. doi: 10.1002/pbc.29415. Epub 2021 Oct 28.
The aim of this study was to evaluate the diagnostic accuracy of -fluorodeoxyglucose-positron emission tomography ( F-FDG PET) and PET/computed tomography (PET/CT) in imaging primary and metastatic lesions in Ewing sarcoma (ES).
PubMed, Cochrane, Scopus, and Web of Science were searched for relevant studies. Data concerning F-FDG PET/CT diagnostic accuracy were extracted and then analyzed using Open Meta-analyst software. Reported diagnostic accuracy outcomes included sensitivity, specificity, negative likelihood ratio (NLR), positive likelihood ratio (PLR), and diagnostic odds ratio.
Thirty-one studies with a total of 735 patients were included in this meta-analysis. The sensitivity and specificity of F-FDG PET/CT were: 92.6% and 74.1% for total ES lesions, 96.7% and 68.3% for ES primary lesions, 76.1% and 92.4% for lung metastasis, 83.9% and 93.2% for bone metastasis, and 89.9% and 92.6% for ES recurrence, respectively.
F-FDG PET/CT is sensitive and accurate in diagnosing, staging, and detecting the recurrence of ES compared with non-PET imaging. It has high accuracy for diagnosing recurrence of ES in bone metastases; however, CT remains a superior diagnostic method for detecting lung metastasis.
本研究旨在评估¹⁸F-氟脱氧葡萄糖正电子发射断层扫描（¹⁸F-FDG PET）及PET/计算机断层扫描（PET/CT）对尤因肉瘤（ES）原发灶及转移灶的诊断准确性。
检索PubMed、Cochrane、Scopus及科学网以查找相关研究。提取有关¹⁸F-FDG PET/CT诊断准确性的数据，然后使用Open Meta-analyst软件进行分析。报告的诊断准确性结果包括敏感性、特异性、阴性似然比（NLR）、阳性似然比（PLR）及诊断比值比。
本荟萃分析纳入了31项研究，共735例患者。¹⁸F-FDG PET/CT对ES总病灶的敏感性和特异性分别为：92.6%和74.1%；对ES原发灶为96.7%和68.3%；对肺转移为76.1%和92.4%；对骨转移为83.9%和93.2%；对ES复发为89.9%和92.6%。
与非PET成像相比，¹⁸F-FDG PET/CT在诊断、分期及检测ES复发方面敏感且准确。其对诊断骨转移中的ES复发具有较高准确性；然而，CT仍是检测肺转移的更优诊断方法。
