Huang Tao, Li Feng, Yan Zexing, Ma Yupeng, Xiong Fei, Cai Xia, Zhang Qingyu, Liu Fanxiao, Dong Jinlei
Department of Orthopaedics, Yantai Shan Hospital, Yantai.
Department of Orthopaedics, Zhangqiu District People's Hospital of Jinan City, Zhangqiu District, Jinan City, Shandong Province, China.
Medicine (Baltimore). 2018 Nov;97(48):e13457. doi: 10.1097/MD.0000000000013457.
To investigate the value of positron emission tomography (PET) and PET/computed tomography (CT) using fluorine-18-fluorodeoxyglucose (F-FDG) in the diagnosis, staging, restaging and recurrence monitoring of Ewing sarcoma family of tumors (ESFTs), a meta-analysis was performed through systematically searching PubMed, Embase, and Cochrane Central library to retrieve articles.
After screening and diluting out the articles that met inclusion criteria to be used for statistical analysis the pooled evaluation indexes including sensitivity, specificity, and diagnostic odd ratio (DOR) as well as the summary receiver operating characteristic curve (SROC) were calculated involving diagnostic data (true positive, false positive, false negative, and true negative) extracted from original studies.
Screening determined that out of 2007, 23 studies involving a total of 524 patients were deemed viable for inclusion in the meta-analysis. The results of the analysis showed that the sensitivity and specificity were at 86% and 80%, respectively. Additionally, a satisfactory accuracy of F-FDG PET and PET/CT was observed in detecting ESFT recurrence, lung metastasis, and osseous metastasis.
This meta-analysis suggests that F-FDG PET and PET/CT with an extremely high accuracy could be considered a valuable method for detecting distant metastasis and post-operational recurrence of ESFT, which might have a profound impact on the development of treatment protocols for ESFT.
为了研究使用氟-18-氟脱氧葡萄糖（F-FDG）的正电子发射断层扫描（PET）及PET/计算机断层扫描（CT）在尤因肉瘤家族性肿瘤（ESFTs）的诊断、分期、再分期及复发监测中的价值，通过系统检索PubMed、Embase和Cochrane中心图书馆来检索文章，进行了一项荟萃分析。
筛选并剔除符合纳入标准用于统计分析的文章后，计算包括敏感性、特异性和诊断比值比（DOR）在内的合并评估指标以及汇总的受试者工作特征曲线（SROC），这涉及从原始研究中提取的诊断数据（真阳性、假阳性、假阴性和真阴性）。
筛选确定，在2007项研究中，有23项研究共涉及524例患者被认为可纳入荟萃分析。分析结果显示敏感性和特异性分别为86%和80%。此外，在检测ESFT复发、肺转移和骨转移方面，观察到F-FDG PET和PET/CT具有令人满意的准确性。
这项荟萃分析表明，具有极高准确性的F-FDG PET和PET/CT可被视为检测ESFT远处转移和术后复发的有价值方法，这可能对ESFT治疗方案的制定产生深远影响。
