Suppr超能文献

围手术期肺不张:第二部分. 临床意义。

Perioperative Pulmonary Atelectasis: Part II. Clinical Implications.

机构信息

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

the Department of Anesthesiology, University of Colorado, Aurora, Colorado.

出版信息

Anesthesiology. 2022 Jan 1;136(1):206-236. doi: 10.1097/ALN.0000000000004009.

Abstract

The development of pulmonary atelectasis is common in the surgical patient. Pulmonary atelectasis can cause various degrees of gas exchange and respiratory mechanics impairment during and after surgery. In its most serious presentations, lung collapse could contribute to postoperative respiratory insufficiency, pneumonia, and worse overall clinical outcomes. A specific risk assessment is critical to allow clinicians to optimally choose the anesthetic technique, prepare appropriate monitoring, adapt the perioperative plan, and ensure the patient's safety. Bedside diagnosis and management have benefited from recent imaging advancements such as lung ultrasound and electrical impedance tomography, and monitoring such as esophageal manometry. Therapeutic management includes a broad range of interventions aimed at promoting lung recruitment. During general anesthesia, these strategies have consistently demonstrated their effectiveness in improving intraoperative oxygenation and respiratory compliance. Yet these same intraoperative strategies may fail to affect additional postoperative pulmonary outcomes. Specific attention to the postoperative period may be key for such outcome impact of lung expansion. Interventions such as noninvasive positive pressure ventilatory support may be beneficial in specific patients at high risk for pulmonary atelectasis (e.g., obese) or those with clinical presentations consistent with lung collapse (e.g., postoperative hypoxemia after abdominal and cardiothoracic surgeries). Preoperative interventions may open new opportunities to minimize perioperative lung collapse and prevent pulmonary complications. Knowledge of pathophysiologic mechanisms of atelectasis and their consequences in the healthy and diseased lung should provide the basis for current practice and help to stratify and match the intensity of selected interventions to clinical conditions.

摘要

肺不张在外科患者中很常见。肺不张可导致手术期间和手术后出现不同程度的气体交换和呼吸力学障碍。在最严重的情况下,肺塌陷可导致术后呼吸功能不全、肺炎和更差的整体临床结局。因此,进行特定的风险评估至关重要,这有助于临床医生优化选择麻醉技术、准备适当的监测、调整围手术期计划,并确保患者安全。床边诊断和管理得益于最近的成像技术进步,如肺部超声和电阻抗断层成像,以及监测技术,如食管测压。治疗管理包括广泛的干预措施,旨在促进肺复张。在全身麻醉期间,这些策略一致证明可有效改善术中氧合和呼吸顺应性。然而,这些相同的术中策略可能无法影响术后肺部的其他结果。因此,术后期间的特定关注可能是影响肺部扩张的关键。对于那些肺不张风险较高的特定患者(例如肥胖患者)或那些有肺塌陷临床表现的患者(例如腹部和心胸手术后的术后低氧血症),无创性正压通气支持等干预措施可能是有益的。术前干预措施可能为最小化围手术期肺不张和预防肺部并发症提供新的机会。了解肺不张的病理生理机制及其在健康和患病肺中的后果,应成为当前实践的基础,并有助于对选定干预措施的强度进行分层和匹配,以适应临床情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c898/9885487/a207c950b680/nihms-1738234-f0001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验