Clinic of Dermatology, Konya Ereğli State Hospital, Konya, Turkey.
Department of Dermatology, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey.
Int J Clin Pract. 2021 Dec;75(12):e14994. doi: 10.1111/ijcp.14994. Epub 2021 Nov 6.
Behcet's disease is an inflammatory vasculitis, and pathergy reaction is a compulsory element of the diagnostic criteria. In the literature, there is no study comparing the histopathology of negative pathergy tests and positive pathergy tests in newly diagnosed Behcet's patients. The primary goal was to investigate the frequency of vasculitis, which is an important finding of Behcet's disease, in pathergy histopathology.
The histopathology of patients with positive and negative pathergy tests revealed vasculitis or vasculopathy. In histopathology, neutrophils, lymphocytes, eosinophils, and mast cells in the perivascular area were counted and recorded as a percentage.
Of the 88 Behcet's patients who participated in the study, 45 were female and 43 were male. The rate of vasculitis in the histopathology of those who were positive for the pathergy test was not statistically different than those of those with negative pathergy tests (P = .14). In our study, although the relationship between the male gender and uveitis was significant at the border, and the relationship between pathergy positivity and uveitis was not found to be significant, a significant relationship was found between vasculitis in histopathology and uveitis (P = .023).
Based on the results of our study, we think that a pathergy test of histopathology will contribute to the clinical diagnostic evaluation in cases with suspicious clinical pathergy tests and especially in cases with negative pathergy tests.
白塞病是一种炎症性血管炎，针刺反应是诊断标准的强制性要素。在文献中，没有研究比较新诊断的白塞病患者中针刺反应阴性和阳性的组织病理学。主要目的是研究血管炎的频率，这是白塞病的一个重要发现，在针刺反应的组织病理学中。
阳性和阴性针刺反应患者的组织病理学显示血管炎或血管病变。在组织病理学中，对血管周围区域的中性粒细胞、淋巴细胞、嗜酸性粒细胞和肥大细胞进行计数并记录为百分比。
在参加研究的 88 名白塞病患者中，45 名是女性，43 名是男性。针刺反应阳性患者的组织病理学中血管炎的发生率与针刺反应阴性患者无统计学差异（P=.14）。在我们的研究中，尽管男性和葡萄膜炎之间的关系在边界上具有显著性，针刺反应阳性与葡萄膜炎之间的关系没有显著性，但组织病理学中的血管炎与葡萄膜炎之间存在显著性关系（P=.023）。
根据我们的研究结果，我们认为组织病理学的针刺反应试验将有助于对可疑临床针刺反应试验的临床诊断评估，特别是在针刺反应阴性的情况下。
