皮肤外科清洁对白塞病同形反应现象的影响。
Effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome.
作者信息
Fresko I, Yazici H, Bayramiçli M, Yurdakul S, Mat C
机构信息
Department of Internal Medicine, Cerrahpaşa Medical Faculty, Istanbul, Turkey.
出版信息
Ann Rheum Dis. 1993 Aug;52(8):619-20. doi: 10.1136/ard.52.8.619.
OBJECTIVES
To assess the effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome.
METHODS
The pathergy phenomenon was assessed in 183 patients with Behçet's syndrome in a single blind study at 48 hours after a needle prick of the forearm skin, cleaned in the conventional way with alcohol, with 10% povidine iodine, with 100% chlorhexidine, and with a 4% aqueous solution of chlorhexidine.
RESULTS
The surgical cleaning of the forearm with povidone iodine before the application of the needle prick reduced the prevalence of the pathergy reaction to 27% from 48% in the conventionally (by alcohol swab) cleaned forearm. Cleaning the forearm with 100% chlorhexidine reduced the prevalence of the pathergy to 36% from 59% in the conventionally cleaned forearm. No significant changes were observed with a 4% aqueous solution of chlorhexidine.
CONCLUSIONS
Surgical cleaning of the skin with disinfectants of various concentrations reduces the prevalence of a positive pathergy test in Behçet's syndrome. This implies that more than the disruption of the structural integrity of the dermis and epidermis is involved in the production of the pathergy phenomenon in Behçet's syndrome.
目的
评估皮肤外科清洁对贝赫切特综合征同形反应的影响。
方法
在一项单盲研究中，对183例贝赫切特综合征患者在前臂皮肤针刺48小时后评估同形反应，分别用酒精、10%聚维酮碘、100%氯己定以及4%氯己定水溶液按常规方法清洁皮肤。
结果
针刺前用聚维酮碘对前臂进行外科清洁，使同形反应的发生率从常规（用酒精擦拭）清洁前臂的48%降至27%。用100%氯己定清洁前臂使同形反应的发生率从常规清洁前臂的59%降至36%。用4%氯己定水溶液清洁未观察到显著变化。
结论
用不同浓度消毒剂对皮肤进行外科清洁可降低贝赫切特综合征中同形试验阳性的发生率。这意味着在贝赫切特综合征同形反应的产生中，涉及的不仅仅是真皮和表皮结构完整性的破坏。
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