University of Wisconsin School of Medicine and Public Health, Department of Family Medicine and Community Health, Madison, Wisconsin,
University of Wisconsin School of Medicine and Public Health, Department of Family Medicine and Community Health, Madison, Wisconsin.
WMJ. 2021 Oct;120(3):233-236.
Little is known about the role of school-aged children and household transmission at the start of the SARS-CoV-2 pandemic. To evaluate for SARS-CoV-2 in school-aged children and assess household transmission, we performed reverse transcription polymerase chain reaction on 670 archived specimens that were collected between September 1, 2019 and June 30, 2020 as part of a community-based study.
A single SARS-CoV-2 case was detected in an 11-year-old girl on March 18, 2020, resulting in very low prevalence (0.15% [95% CI, 0.03-0.84]) in this population. This case was associated with SARS-CoV-2 detection in all other household members. Symptoms were reported as mild to moderate. Whole genome sequencing supported household transmission of near-identical viruses within the 19B clade.
This case represents the earliest known household cluster of SARS-CoV2 in Wisconsin.
This case suggests that household transmission associated with school-aged children may have contributed to wide seeding across populations.
在 SARS-CoV-2 大流行开始时，关于学龄儿童和家庭传播的作用知之甚少。为了评估学龄儿童中是否存在 SARS-CoV-2 并评估家庭传播，我们对 2019 年 9 月 1 日至 2020 年 6 月 30 日期间作为社区研究的一部分收集的 670 个存档标本进行了逆转录聚合酶链反应。
2020 年 3 月 18 日，一名 11 岁女孩检测出单一 SARS-CoV-2 病例，导致该人群的患病率非常低（0.15%[95%CI，0.03-0.84]）。该病例与所有其他家庭成员的 SARS-CoV-2 检测结果相关。症状报告为轻度至中度。全基因组测序支持 19B 亚群中病毒的家庭传播。
该病例代表了威斯康星州最早已知的 SARS-CoV2 家庭聚集。
该病例表明，与学龄儿童相关的家庭传播可能导致人群广泛传播。
