Gasparini M, Tondini C, Rottoli L, Roncoroni I
Am J Clin Oncol. 1987 Apr;10(2):152-5. doi: 10.1097/00000421-198704000-00051.
Fifteen patients with metastatic osteogenic sarcoma (OS) were treated with a combination of Vincristine (1.4 mg/m2), high-dose Methotrexate (8 g/m2), and Cisplatin (120 mg/m2 as a 72-h continuous infusion). The overall response rate was 66% [5 complete response (CR) and 5 partial response (PR)]. Four of the six patients not previously treated had a CR. Toxicity from this regimen was moderate and never life-threatening. In no case was impairment of the renal function observed, and the clearance of high-dose Methotrexate was never delayed.
15例转移性骨肉瘤（OS）患者接受了长春新碱（1.4mg/m²）、大剂量甲氨蝶呤（8g/m²）和顺铂（120mg/m²，持续输注72小时）联合治疗。总缓解率为66%[5例完全缓解（CR）和5例部分缓解（PR）]。6例未接受过治疗的患者中有4例获得CR。该方案的毒性为中度，从未危及生命。未观察到肾功能损害的情况，大剂量甲氨蝶呤的清除也从未延迟。
