School of Preclinical Medicine, Chengdu University, Chengdu 610106, China.
Key Laboratory of Coarse Cereal Processing of Ministry, Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Food Chem. 2022 Mar 30;373(Pt A):131380. doi: 10.1016/j.foodchem.2021.131380. Epub 2021 Oct 11.
As a well-recognized dietary and medicinal plant, Taraxacum mongolicum Hand.-Mazz (TMHM) has been used for making wines, candies, energy drinks, and other functional foods. The TMHM contains a diverse range of active phytoconstituents, including flavonoids, triterpenoids, phenolic acids, sesquiterpene lactones, pigments, coumarins and sterols. Recent pharmacological evidence has revealed multiple biological effects of TMHM, including anti-inflammatory, antioxidant, antibacterial, and gastric-protective effects, which contribute to the ameliorative effects of TMHM on inflammation-associated diseases, constipation, gastric disorders, empyrosis, hyperlipidemia, and swollen carbuncles. Although recent advances have highlighted the potential of TMHM to be applied in the clinical practice, food, and nutraceutical industry, the mechanistic understanding and systematic information on TMHM are still scarce. Here, in this timeline review, we have attempted to compile literary documents on pharmacological potential of TMHM concerning its chemical composition, biological activities, toxicity, and pharmacokinetics to promote further researches on clinical and therapeutic potential of TMHM and its food/nutraceutical applications.
作为一种广为人知的药食两用植物，蒲公英（TMHM）被用于酿造葡萄酒、制作糖果、能量饮料和其他功能性食品。TMHM 含有多种具有生物活性的植物化学成分，包括黄酮类、三萜类、酚酸类、倍半萜内酯类、色素、香豆素和固醇。最近的药理学证据揭示了 TMHM 的多种生物学作用，包括抗炎、抗氧化、抗菌和胃保护作用，这些作用有助于改善 TMHM 对炎症相关疾病、便秘、胃部疾病、痈疽、高血脂和红肿疖子的疗效。尽管最近的进展强调了 TMHM 在临床实践、食品和营养保健品行业的应用潜力，但对 TMHM 的机制理解和系统信息仍然缺乏。在这里，在这个时间线综述中，我们试图汇编有关 TMHM 药理学潜力的文献，包括其化学成分、生物活性、毒性和药代动力学，以促进对 TMHM 的临床和治疗潜力及其在食品/营养保健品中的应用的进一步研究。
