Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China.
Biomaterials. 2021 Dec;279:121211. doi: 10.1016/j.biomaterials.2021.121211. Epub 2021 Oct 22.
The inability of adult mammals to recover function lost after severe spinal cord injury (SCI) has been known for millennia and is mainly attributed to a failure of brain-derived nerve fiber regeneration across the lesion. Potential approaches to re-establishing locomotor function rely on neuronal relays to reconnect the segregated neural networks of the spinal cord. Intense research over the past 30 years has focused on endogenous and exogenous neuronal relays, but progress has been slow and the results often controversial. Treatments with stem cell-derived neuronal relays alone or together with functional electrical stimulation offer the possibility of improved repair of neuronal networks. In this review, we focus on approaches to recovery of motor function in paralyzed patients after severe SCI based on novel therapies such as implantation of stem cell-derived neuronal relays and functional electrical stimulation. Recent research progress offers hope that SCI patients will one day be able to recover motor function and sensory perception.
成年哺乳动物在严重脊髓损伤（SCI）后丧失功能无法恢复的现象已存在了数千年，主要归因于大脑源性神经纤维无法穿过损伤部位再生。潜在的恢复运动功能的方法依赖于神经元中继，以重新连接脊髓的分隔神经网络。过去 30 年，人们对内在和外在的神经元中继进行了深入研究，但进展缓慢，结果往往存在争议。单独使用干细胞源性神经元中继或与功能性电刺激一起治疗，为改善神经元网络修复提供了可能。在这篇综述中，我们专注于严重 SCI 后瘫痪患者基于新疗法（如干细胞源性神经元中继和功能性电刺激的植入）恢复运动功能的方法。最近的研究进展为 SCI 患者有一天能够恢复运动功能和感觉感知带来了希望。
